Volume 4, Issue 7, Pages (August 2018)

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Volume 4, Issue 7, Pages 716-718 (August 2018) Cutaneous metastases of malignant peripheral nerve sheath tumor: Ineffectiveness of intralesional methotrexate Claire E. Hannah, BS, Molly S. Moye, MD, Vincent Liu, MD, Mohammed M. Milhem, MBBS, Karolyn A. Wanat, MD JAAD Case Reports Volume 4, Issue 7, Pages 716-718 (August 2018) DOI: 10.1016/j.jdcr.2018.04.011 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Cutaneous metastasis of malignant peripheral nerve sheath tumor. Firm, pink nodule measuring 1.6 × 0.8 cm on right temporal scalp at the time of initial consultation with the dermatology department. B, Right temporal scalp metastasis measuring 6.8 × 5.7 cm 2 weeks after the second injection of intralesional methotrexate. This photograph was taken approximately 5 weeks after the photograph in Fig 1, A. JAAD Case Reports 2018 4, 716-718DOI: (10.1016/j.jdcr.2018.04.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Cutaneous metastasis of malignant peripheral nerve sheath tumor. Biopsy of the right temporal scalp nodule shows small nests and strands of deeply infiltrative tumor cells with marked nuclear pleomorphism and high mitotic activity. The specimen stained positively for S100, but negatively for MITF. (Hematoxylin-eosin stain; original magnification: ×400.) JAAD Case Reports 2018 4, 716-718DOI: (10.1016/j.jdcr.2018.04.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Cutaneous metastasis of malignant peripheral nerve sheath tumor. Rapid growth of firm neck nodules that developed within 3 weeks of the patient's initial presentation to the dermatology department. JAAD Case Reports 2018 4, 716-718DOI: (10.1016/j.jdcr.2018.04.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions