When is it Best to Repeat a 2-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography/Computed Tomography Scan on Patients with Non-Small Cell Lung Cancer.

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Presentation transcript:

When is it Best to Repeat a 2-Fluoro-2-Deoxy-d-Glucose Positron Emission Tomography/Computed Tomography Scan on Patients with Non-Small Cell Lung Cancer Who Have Received Neoadjuvant Chemoradiotherapy? Robert James Cerfolio, MD, Ayesha S. Bryant, MSPH, MD The Annals of Thoracic Surgery Volume 84, Issue 4, Pages 1092-1097 (October 2007) DOI: 10.1016/j.athoracsur.2007.05.050 Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Algorithm for the restaging of patients with stage IIIa (N2) non-small cell lung cancer after neoadjuvant chemoradiotherapy using cisplatinum-based chemotherapy and concurrent high dose (60 Gy or greater) of radiotherapy. (CT = computed tomography; maxSUV = maximum standardized uptake value; PET = positron emission tomography.) The Annals of Thoracic Surgery 2007 84, 1092-1097DOI: (10.1016/j.athoracsur.2007.05.050) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Accuracy of integrated 2-fluoro-2-deoxy-d-glucose positron emission tomography (PET)/computed tomography scan for restaging, overall (gray bars) and for N2 disease (black bars) based on the time interval between the last dose of radiotherapy and the repeat PET scan. The Annals of Thoracic Surgery 2007 84, 1092-1097DOI: (10.1016/j.athoracsur.2007.05.050) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Receiver operating characteristic curve (black line) with 95% confidence intervals (gray lines) shows the optimal time to perform a repeat positron emission tomography scan after neoadjuvant chemoradiotherapy therapy for overall staging, which was 26 days after last dose of radiotherapy (area under the curve, diagonal line, 0.88). The Annals of Thoracic Surgery 2007 84, 1092-1097DOI: (10.1016/j.athoracsur.2007.05.050) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Receiver operating characteristic curve (black line) with 95% confidence intervals (gray lines) shows the optimal time to perform a repeat positron emission tomography scan after neoadjuvant chemoradiotherapy for N2 restaging, which was 29 days after the last dose of radiotherapy (area under the curve, diagonal line, 0.82). All 97 patients with IIIa (N2) disease had biopsy-proven N2 nodes and then underwent rebiopsy or removal of the same node after neoadjuvant therapy. The Annals of Thoracic Surgery 2007 84, 1092-1097DOI: (10.1016/j.athoracsur.2007.05.050) Copyright © 2007 The Society of Thoracic Surgeons Terms and Conditions