Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological.

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Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study Yang Wang, PhD, Guo-Bao Tian, PhD, Rong Zhang, PhD, Yingbo Shen, Jonathan M Tyrrell, PhD, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, PhD, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, PhD, Kun-Jiao Zeng, Shaolin Wang, PhD, Prof Jian-Hua Liu, PhD, Prof Congming Wu, PhD, Prof Timothy R Walsh, DSc, Prof Jianzhong Shen, PhD The Lancet Infectious Diseases Volume 17, Issue 4, Pages 390-399 (April 2017) DOI: 10.1016/S1473-3099(16)30527-8 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Flowchart diagram of samples collection in two hospitals in Zhejiang and Guangdong provinces P aeruginosa=Pseudomonas aeruginosa. E coli=Escherichia coli. K pneumoniae=Klebsiella pneumoniae. E cloacae=Enterobacter cloacae. E aerogenes=Enterobacter aerogenes. S marcescens=Serratia marcescens. MCRPEC=mcr-1-positive Escherichia coli. The Lancet Infectious Diseases 2017 17, 390-399DOI: (10.1016/S1473-3099(16)30527-8) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Minimum spanning trees of mcr-1-positive Escherichia coli by MLST type and gene allele profile for Guangdong (A) and Zhejiang (B) Each node within the tree represents a single ST. The size of the nodes is proportional to the number of isolates represented by said node. Length of branches between each node is proportional to the number of different alleles (out of seven MLST genes) that differ between two linked nodes/ST. Selected nodes are labelled with corresponding ST, phylogenetic group, and number of isolates represented. New STs identified are in blue. MLST=multi-locus sequence typing. ST=sequence type. The Lancet Infectious Diseases 2017 17, 390-399DOI: (10.1016/S1473-3099(16)30527-8) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 3 Minimum spanning tree of mcr-1-positive Escherichia coli by MLST type and gene allele from colonised patients from hospitals and colonised healthy volunteers Each node within the tree represents a single ST. The size of the nodes is proportional to the number of isolates represented by said node. Length of branches between each node represents the number of different alleles (out of seven MLST genes) that differ between two linked nodes/ST. Selected nodes are labelled with corresponding ST, phylogenetic group, and number of isolates represented. New STs identified with the blue border. MLST=multilocus sequence typing. ST=sequence type. The Lancet Infectious Diseases 2017 17, 390-399DOI: (10.1016/S1473-3099(16)30527-8) Copyright © 2017 Elsevier Ltd Terms and Conditions