A.Y Onaolapo, A.A. Adebayo, O.J Onaolapo Pathophysiology

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Oral phenytoin protects against experimental cyclophosphamide-chemotherapy induced hair loss A.Y Onaolapo, A.A. Adebayo, O.J Onaolapo Pathophysiology Volume 25, Issue 1, Pages 31-39 (March 2018) DOI: 10.1016/j.pathophys.2017.12.001 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 Effect of phenytoin on percentage weight change. Values are means±S.E.M. (*p<0.05 significantly different from VEH, #p<0.05 significantly different from CYP, &p<0.005 significantly different from Phenytoin, VEH: vehicle, CYP: cyclophosphamide, PHE 50: phenytoin at 50mg/kg, PHE 100: phenytoin at 100mg/kg, number of animals per group-6. Pathophysiology 2018 25, 31-39DOI: (10.1016/j.pathophys.2017.12.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Photodocumentation of the effect of phenytoin with or without chemotherapy-induced alopecia in rats. 2A –vehicle, 2B –Phenytoin at 50mg/kg, 2C-Phenytoin at 100mg/kg, 2D- cyclophosphamide control, 2E-cyclophosphamide and phenytoin at 50mg/kg, 2F- cyclophosphamide and phenytoin at 100mg/kg. Photographs were taken on days 9, 23 and 37 respectively, number of animals per group-6. Pathophysiology 2018 25, 31-39DOI: (10.1016/j.pathophys.2017.12.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Photomicrographs of representative hair strands from all groups. 3A –vehicle, 3B −Phenytoin at 50mg/kg, 3C-Phenytoin at 100mg/kg, 3D- cyclophosphamide control, 3E-cyclophosphamide and phenytoin at 50mg/kg, 3F- cyclophosphamide and phenytoin at 100mg/kg,C: cortex, M: medulla, number of animals per group-6. Pathophysiology 2018 25, 31-39DOI: (10.1016/j.pathophys.2017.12.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 4 Effect of phenytoin on colour intensity of hair strand. Values are means±S.E.M. (*p<0.05 significantly different from VEH, #p<0.05 significantly different from CYP, &p<0.005 significantly different from PHE, VEH: vehicle, CYP: cyclophosphamide, PHE 50: phenytoin at 50mg/kg, PHE 100: phenytoin at 100mg/kg, number of animals per group-6. Pathophysiology 2018 25, 31-39DOI: (10.1016/j.pathophys.2017.12.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 5 Effect of phenytoin on mean width of cortex (upper panel) and mean width of medulla (lower panel) of hair strand. Values are means±S.E.M. (*p<0.05 significantly different from VEH, #p<0.05 significantly different from CYP, &p<0.005 significantly different from PHE, VEH: vehicle, CYP: cyclophosphamide, PHE 50: phenytoin at 50mg/kg, PHE 100: phenytoin at 100mg/kg, number of animals per group-6. Pathophysiology 2018 25, 31-39DOI: (10.1016/j.pathophys.2017.12.001) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 6 Photomicrographs of representative skin samples from all groups showing hair follicle, hair bulb, hair shaft, and external root sheath. dg hair: degenerating hair follicle. 6A –vehicle, 6B –Phenytoin at 50mg/kg, 6C-Phenytoin at 100mg/kg, 6D- cyclophosphamide control, 6E-cyclophosphamide and phenytoin at 50mg/kg, 6F- cyclophosphamide and phenytoin at 100mg/kg, number of animals per group-6. Pathophysiology 2018 25, 31-39DOI: (10.1016/j.pathophys.2017.12.001) Copyright © 2017 Elsevier B.V. Terms and Conditions