Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations Kirsten M. Kloepfer,

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Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations Kirsten M. Kloepfer, MD, MS, Wai Ming Lee, PhD, Tressa E. Pappas, BS, Theresa J. Kang, BS, Rose F. Vrtis, BS, Michael D. Evans, MS, Ronald E. Gangnon, PhD, Yury A. Bochkov, PhD, Daniel J. Jackson, MD, Robert F. Lemanske, MD, James E. Gern, MD Journal of Allergy and Clinical Immunology Volume 133, Issue 5, Pages 1301-1307.e3 (May 2014) DOI: 10.1016/j.jaci.2014.02.030 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Weekly pathogen detection compared with concurrent weekly respiratory symptoms. Weekly specimens of nasal secretions were analyzed for rhinovirus (RV) and bacteria, and pathogen detection was compared with weekly measures of respiratory symptoms, including cold symptoms (A-C), asthma symptoms (D-F), and moderate asthma exacerbations (G-I). xP < .05 versus no pathogen, +P < .05 versus bacteria only, and #P < .05 versus rhinovirus only. Journal of Allergy and Clinical Immunology 2014 133, 1301-1307.e3DOI: (10.1016/j.jaci.2014.02.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A-C, Probability of experiencing illness symptoms according to patterns of pathogen detection. Each illness was matched with an asymptomatic period of the same length, and the probability of pathogen detection was compared. D-F, Within the asthma group, the probability of experiencing an asthma exacerbation with pathogen detection was also compared. *P < .05. Journal of Allergy and Clinical Immunology 2014 133, 1301-1307.e3DOI: (10.1016/j.jaci.2014.02.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Subjects included in analysis. Journal of Allergy and Clinical Immunology 2014 133, 1301-1307.e3DOI: (10.1016/j.jaci.2014.02.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions