Decreased proteoglycan degradation in IL-1β-treated cartilage co-cultured with TIMP-3- transduced cells J. Mason, A. Donahue, A. Yoskowitz, D. Richardson

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Decreased proteoglycan degradation in IL-1β-treated cartilage co-cultured with TIMP-3- transduced cells J. Mason, A. Donahue, A. Yoskowitz, D. Richardson Osteoarthritis and Cartilage Volume 21, Pages S207-S208 (April 2013) DOI: 10.1016/j.joca.2013.02.432 Copyright © 2013 Terms and Conditions

Figure 1 Glycosaminoglycan changes in articular cartilage before and after in vitro-culture. IL-1β significantly decreased the amount of GAG contained in cartilage post-culture. Error bars represent SE. Osteoarthritis and Cartilage 2013 21, S207-S208DOI: (10.1016/j.joca.2013.02.432) Copyright © 2013 Terms and Conditions

Figure 2 Glycosaminoglycan changes in articular cartilage exposed to TIMP-3. Co-culture with TIMP-3-transduced cells significantly increased the amount of GAG contained in IL-1β-cultured cartilage. Error bars represent SE. Osteoarthritis and Cartilage 2013 21, S207-S208DOI: (10.1016/j.joca.2013.02.432) Copyright © 2013 Terms and Conditions

Figure 3 Aggrecan changes in articular cartilage exposed to TIMP-3. Co-culture with TIMP-3-transduced cells significantly decreased the amount of the degraded -aggrecan fragment, ARGSVIL released into the media of IL-1β-cultured cartilage. Error bars represent SE. Osteoarthritis and Cartilage 2013 21, S207-S208DOI: (10.1016/j.joca.2013.02.432) Copyright © 2013 Terms and Conditions