Deep morphea induced by interferon-β1b injection

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Presentation transcript:

Deep morphea induced by interferon-β1b injection Erika Yue Lee, BSc Hon, Steven Jeremy Glassman, MD JAAD Case Reports Volume 2, Issue 3, Pages 236-238 (May 2016) DOI: 10.1016/j.jdcr.2016.04.003 Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Morphea profunda: an erythematous, ill-defined plaque at the site of IFN-β1b injection on the right anterior thigh. Biopsy site shown. B, Follow-up: decreased erythema and induration of plaques on both thighs after treatment with prednisone and methotrexate for 8 months. The small superficial scar on the right thigh was from the biopsy, and the scar on the left thigh was from incision and drainage. JAAD Case Reports 2016 2, 236-238DOI: (10.1016/j.jdcr.2016.04.003) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Normal epidermis with dermal sclerosis extending to subcutis. Perivascular and periadnexal lymphocytic infiltrate with eosinophils. Reduced periadnexal fat. (Hematoxylin-eosin stain; original magnification: ×40.) JAAD Case Reports 2016 2, 236-238DOI: (10.1016/j.jdcr.2016.04.003) Copyright © 2016 American Academy of Dermatology, Inc. Terms and Conditions