The chitinase-like protein YKL-40: A possible biomarker of inflammation and airway remodeling in severe pediatric asthma Jon R. Konradsen, MD, PhD, Anna.

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Presentation transcript:

The chitinase-like protein YKL-40: A possible biomarker of inflammation and airway remodeling in severe pediatric asthma Jon R. Konradsen, MD, PhD, Anna James, PhD, Björn Nordlund, RN, Lovisa E. Reinius, PhD, Cilla Söderhäll, PhD, Erik Melén, MD, PhD, Åsa Wheelock, PhD, Karin C. Lödrup Carlsen, MD, PhD, Marika Lidegran, MD, PhD, Marri Verhoek, Rolf G. Boot, PhD, Barbro Dahlén, MD, PhD, Sven Erik Dahlén, MD, PhD, Gunilla Hedlin, MD, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 2, Pages 328-335.e5 (August 2013) DOI: 10.1016/j.jaci.2013.03.003 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow of patients from referral to final inclusion. CA, Controlled persistent asthma; PA, problematic severe asthma. Journal of Allergy and Clinical Immunology 2013 132, 328-335.e5DOI: (10.1016/j.jaci.2013.03.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of serum levels of YKL-40 in children with severe, therapy-resistant asthma, children with controlled persistent asthma, and healthy controls. Results are presented as individual data points with median bars. Journal of Allergy and Clinical Immunology 2013 132, 328-335.e5DOI: (10.1016/j.jaci.2013.03.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Correlations between YKL-40 levels, asthma control, Feno, neutrophils, and bronchial wall thickening among children with severe, therapy-resistant asthma. Journal of Allergy and Clinical Immunology 2013 132, 328-335.e5DOI: (10.1016/j.jaci.2013.03.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 The effect of genetic variability on chitinase levels in all asthmatic subjects. Serum YKL-40 levels are categorized according to CHI3L1 genotype (rs4950928) and asthma severity. Results from children with controlled asthma (●) and children with severe, therapy-resistant asthma (■) are displayed as individual data points with median bars. Journal of Allergy and Clinical Immunology 2013 132, 328-335.e5DOI: (10.1016/j.jaci.2013.03.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Comparison of serum levels of chitotriosidase activity in children with severe, therapy-resistant asthma, children with controlled persistent asthma, and healthy controls. Results are presented as individual data points with median bars. Journal of Allergy and Clinical Immunology 2013 132, 328-335.e5DOI: (10.1016/j.jaci.2013.03.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 The effect of CHIT1 rs 3831317 genotype on serum chitotriosidase activity in all asthmatic subjects. The CHIT1 24-bp duplication (rs3831317) results in a nonfunctional protein lacking enzymatic activity. Children were grouped into those lacking the 24-bp duplication in exon 10 (75/75 bp homozygous, wild-type), heterozygote carriers (75/99 bp), and those homozygous for the duplication (99/99 bp). Results from children with controlled asthma (●) and children with severe, therapy-resistant asthma (■) are displayed as individual data points with median bars. Journal of Allergy and Clinical Immunology 2013 132, 328-335.e5DOI: (10.1016/j.jaci.2013.03.003) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions