Volume 388, Issue 10059, Pages (November 2016)

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Volume 388, Issue 10059, Pages 2501-2509 (November 2016) Parent-mediated social communication therapy for young children with autism (PACT): long-term follow-up of a randomised controlled trial Prof Andrew Pickles, PhD, Prof Ann Le Couteur, FRCPsych, Kathy Leadbitter, PhD, Erica Salomone, PhD, Rachel Cole-Fletcher, PhD, Hannah Tobin, BSc, Isobel Gammer, MSc, Jessica Lowry, MSc, George Vamvakas, MSc, Prof Sarah Byford, PhD, Catherine Aldred, PhD, Vicky Slonims, PhD, Prof Helen McConachie, PhD, Prof Patricia Howlin, PhD, Jeremy R Parr, MD, Prof Tony Charman, PhD, Prof Jonathan Green, FRCPsych The Lancet Volume 388, Issue 10059, Pages 2501-2509 (November 2016) DOI: 10.1016/S0140-6736(16)31229-6 Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 1 Profile of PACT trial plus follow-up study The Lancet 2016 388, 2501-2509DOI: (10.1016/S0140-6736(16)31229-6) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 2 Effect estimates and 95% bootstrap CIs Plot shows log-odds and Cohen's d effect sizes for PACT versus treatment as usual comparisons (effect estimates and 95% bootstrap CIs). PACT=preschool autism communication trial. ADOS CSS=Autism Diagnostic Observation Schedule Comparative Severity Score. SCQ=Social Communication Questionnaire. RBQ=Repetitive Behaviour Questionnaire. SDQ=Strength and Difficulties Questionnaire. DAWBA=Development and Well-Being Assessment. OCD=obsessive compulsive disorder. The Lancet 2016 388, 2501-2509DOI: (10.1016/S0140-6736(16)31229-6) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 3 Course of outcomes by group from baseline to follow-up Group time-paths relative to baseline (left) and PACT relative to treatment as usual (right). Bars represent time-specific estimates with 95% CIs from repeated measures models and p values for area test of no-difference between group profiles. PACT=preschool autism communication trial. ADOS CSS=Autism Diagnostic Observation Schedule Comparative Severity Score. AUC=area-under-curve estimation. The Lancet 2016 388, 2501-2509DOI: (10.1016/S0140-6736(16)31229-6) Copyright © 2016 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions