Donor KIR Genes 2DL5A, 2DS1 and 3DS1 Are Associated with a Reduced Rate of Leukemia Relapse After HLA-Identical Sibling Stem Cell Transplantation for.

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Presentation transcript:

Donor KIR Genes 2DL5A, 2DS1 and 3DS1 Are Associated with a Reduced Rate of Leukemia Relapse After HLA-Identical Sibling Stem Cell Transplantation for Acute Myeloid Leukemia but Not Other Hematologic Malignancies Kate Stringaris, Sharon Adams, Marcela Uribe, Rhoda Eniafe, Colin O. Wu, Bipin N. Savani, A. John Barrett Biology of Blood and Marrow Transplantation Volume 16, Issue 9, Pages 1257-1264 (September 2010) DOI: 10.1016/j.bbmt.2010.03.004 Copyright © 2010 Terms and Conditions

Figure 1 Factors affecting SCT outcome in multivariate analysis of 261 patients. (A) Lymphocyte count at day 30 posttransplant and TRM; (B) donor KIR genotype and relapse. Biology of Blood and Marrow Transplantation 2010 16, 1257-1264DOI: (10.1016/j.bbmt.2010.03.004) Copyright © 2010 Terms and Conditions

Figure 2 Effect of donor KIR genes on relapse in AML patients (n = 68). (A) Stratified by donor KIR genes; (B) stratified by donor KIR and patient risk group. Biology of Blood and Marrow Transplantation 2010 16, 1257-1264DOI: (10.1016/j.bbmt.2010.03.004) Copyright © 2010 Terms and Conditions