Lucas W. Thornblade, MD, MPH, Michael S

Slides:

Advertisements

Similar presentations

Photodynamic Laser Therapy for Lesions in the Airway

Advertisements

Elizabeth A. David, MD, David T

Jeffrey L. Port, MD, Robert J. Korst, MD, Paul C. Lee, MD, Amanda L

Outcomes of Major Lung Resection After Induction Therapy for Non-Small Cell Lung Cancer in Elderly Patients Chi-Fu Jeffrey Yang, MD, Nicholas R. Mayne,

Lymphovascular Invasion as a Prognostic Indicator in Stage I Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis Nathan M. Mollberg, DO,

Masatsugu Hamaji, MD, Syed Osman Ali, MD, Bryan M. Burt, MD

Serum Biomarkers May Prognosticate Recurrence in Node-Negative, Non-Small Cell Lung Cancers Less Than 4 Centimeters Christopher W. Seder, MD, Andrew.

Melanie Subramanian, MD, Timothy McMurry, PhD, Bryan F

Local recurrence after surgery for non–small cell lung cancer: A recursive partitioning analysis of multi-institutional data Chris R. Kelsey, MD, Kristin.

A Nomogram to Predict Recurrence and Survival of High-Risk Patients Undergoing Sublobar Resection for Lung Cancer: An Analysis of a Multicenter Prospective.

Elliot Wakeam, MD, MPH, Meredith Giuliani, MBBS, MEd, Natasha B

Tumor Necrosis as a Prognostic Factor for Stage IA Non-Small Cell Lung Cancer Seong Yong Park, MD, Hyun-Sung Lee, MD, PhD, Hee-Jin Jang, MD, Geon Kook.

Existing General Population Models Inaccurately Predict Lung Cancer Risk in Patients Referred for Surgical Evaluation James M. Isbell, MD, MSCI, Stephen.

Vascular endothelial growth factor C complements the ability of positron emission tomography to predict nodal disease in lung cancer Farhood Farjah,

Matthew D. Taylor, MD, Alykhan S. Nagji, MD, Castigliano M

Armin Kiankhooy, MD, Matthew D. Taylor, MD, Damien J

Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD

Log Odds of Positive Lymph Nodes Predicts Survival in Patients After Resection for Esophageal Cancer Jinlin Cao, MD, Ping Yuan, MD, Honghai Ma, MD, Peng.

Salvage Lung Resection After Definitive Radiation (>59 Gy) for Non-Small Cell Lung Cancer: Surgical and Oncologic Outcomes Julie E. Bauman, MD, Michael.

A Model to Predict the Use of Surgical Resection for Advanced-Stage Non-Small Cell Lung Cancer Patients Elizabeth A. David, MD, Stina W. Andersen, PhD,

Clinical T2N0 Esophageal Cancer: Identifying Pretreatment Characteristics Associated With Pathologic Upstaging and the Potential Role for Induction Therapy

Induction Chemotherapy is Not Superior to a Surgery-First Strategy for Clinical N1 Non- Small Cell Lung Cancer Paul J. Speicher, MD, Zachary W. Fitch,

Castigliano M. Bhamidipati, DO, MS, George J

Lymph Node Evaluation Achieved by Open Lobectomy Compared With Thoracoscopic Lobectomy for N0 Lung Cancer Robert E. Merritt, MD, Chuong D. Hoang, MD,

Prognostic Predictors in Non-Small Cell Lung Cancer Patients Undergoing Intentional Segmentectomy Terumoto Koike, MD, PhD, Teruaki Koike, MD, PhD, Yasushi.

Trimodal Therapy for Histologically Proven N2/3 Non–Small Cell Lung Cancer: Mid-Term Results and Indicators for Survival Volker Steger, MD, Thorsten.

Andrea S. Wolf, MD, MPH, Scott J

Chris Dickhoff, MD, Max Dahele, MD, PhD, Sayed M

Survival of Patients With or Without Symptoms Undergoing Potentially Curative Resections for Primary Lung Cancer Andrea R.G. Sheel, BS (Hons), MBChB,

Pulmonary Resection in the Treatment of Multidrug-Resistant Tuberculosis: A Retrospective Study of 56 Cases Haifeng Wang, MM, Hongsheng Lin, MM, Gening.

David D. Shersher, MD, Michael S

Resection of Intraabdominal Tumors With Cavoatrial Extension Using Deep Hypothermic Circulatory Arrest Christopher Lau, MD, Padraic O’Malley, MD, Mario.

Asad A. Shah, MD, Mathias Worni, MD, MHS, Christopher R

Andrea S. Wolf, MD, William G. Richards, PhD, Michael T

Impact of Lepidic Component Occupancy on Effects of Adjuvant Chemotherapy for Lung Adenocarcinoma Shinsuke Sasada, MD, PhD, Yoshihiro Miyata, MD, PhD,

Quality Measures in Clinical Stage I Non-Small Cell Lung Cancer: Improved Performance Is Associated With Improved Survival Pamela Samson, MD, MPHS, Traves.

Age-Dependent Gender Disparities in Post Lung Transplant Survival Among Patients With Idiopathic Pulmonary Fibrosis Shahid I. Sheikh, MD, Don Hayes,

Use of Amiodarone After Major Lung Resection

Elliot Wakeam, MD, MPH, James P. Byrne, MD, Gail E

Impact of Blood Product Transfusion on Short and Long-Term Survival After Cardiac Surgery: More Evidence Balu Bhaskar, MD, FCICM, Joel Dulhunty, PhD,

Number of Lymph Nodes Associated With Maximal Reduction of Long-Term Mortality Risk in Pathologic Node-Negative Non–Small Cell Lung Cancer Raymond U.

Alex K. Bryant, BS, Robert C. Mundt, HSDG, Ajay P. Sandhu, MD, James J

Recurrence and Survival After Segmentectomy in Patients With Prior Lung Resection for Early-Stage Non-Small Cell Lung Cancer Lisa M. Brown, MD, Brian.

Differences in Patterns of Recurrence in Early-Stage Versus Locally Advanced Non- Small Cell Lung Cancer Feiran Lou, MD, MS, Camelia S. Sima, MD, MS,

Video-Assisted Thoracoscopic Surgery is More Favorable Than Thoracotomy for Resection of Clinical Stage I Non-Small Cell Lung Cancer Bryan A. Whitson,

Interaction of Donor and Recipient Age: Do Older Heart Transplant Recipients Require Younger Hearts? Malini Daniel, MD, Carol Chen, MD, Jennifer Chung,

Eric S. Weiss, MD, MPH, Jeremiah G. Allen, MD, Christian A

Sublobar Resection Provides an Equivalent Survival After Lobectomy in Elderly Patients With Early Lung Cancer Jiro Okami, MD, PhD, Yuri Ito, PhD, Masahiko.

Characteristics of Malignant Pleural Mesothelioma in Women

Lucas W. Thornblade, MD, Aaron M. Cheng, MD, Douglas E

Radiofrequency Ablation for Stage I Non-Small Cell Lung Cancer: Management of Locoregional Recurrence Michael Lanuti, MD, Amita Sharma, MD, Henning Willers,

It’s All in the “Swerve of the Curve”

The Influence of Physician and Patient Gender on Risk Assessment for Lung Cancer Resection Mark K. Ferguson, MD, Megan Huisingh-Scheetz, MD, MPH, Katherine.

Visceral Pleural Invasion Is Not Predictive of Survival in Patients With Lung Cancer and Smaller Tumor Size Elizabeth David, MD, Peter F. Thall, PhD,

Sebastien Gilbert, MD, Sonam Maghera, BS, Andrew J

Shared Decision Making and Effective Risk Communication in the High-Risk Patient With Operable Stage I Non-Small Cell Lung Cancer Pamela Samson, MD,

Resected Synchronous Primary Malignant Lung Tumors: A Population-Based Study Hans Rostad, MD, PhD, Trond-Eirik Strand, MD, Anne Naalsund, MD, Jarle Norstein,

Prolonged Intensive Care Unit Stay in Cardiac Surgery: Risk Factors and Long-Term- Survival Ortrud Vargas Hein, MD, Jürgen Birnbaum, MD, Klaus Wernecke,

Prognostic Heterogeneity in Multilevel N2 Non-Small Cell Lung Cancer Patients: Importance of Lymphadenopathy and Occult Intrapulmonary Metastases Yukinori.

Effects of Delayed Surgical Resection on Short-Term and Long-Term Outcomes in Clinical Stage I Non-Small Cell Lung Cancer Pamela Samson, MD, Aalok Patel,

Matthew J. Schuchert, MD, Omar Awais, DO, Ghulam Abbas, MD, Zachary D

Effect of Formalin Fixation on Tumor Size Determination in Stage I Non-Small Cell Lung Cancer Po-Kuei Hsu, MD, Hsu-Chih Huang, MD, Chih-Cheng Hsieh,

Role of Positron Emission Tomography/Computed Tomography Findings for Adjuvant Chemotherapy Indications in Stage T1b-2aN0M0 Lung Adenocarcinoma Shinsuke.

Creation of a Quantitative Score to Predict the Need for Mechanical Support in Children Awaiting Heart Transplant Ryan R. Davies, MD, Shylah Haldeman,

Clinical Outcome After Pulmonary Resection for Lung Cancer Patients on Hemodialysis Toshiro Obuchi, MD, Wakako Hamanaka, MD, Yasuhiro Yoshida, MD, Jun.

Survival and Outcomes of Pulmonary Resection for Non-Small Cell Lung Cancer in the Elderly: A Nested Case-Control Study Robert J. Cerfolio, MD, Ayesha.

Mark I. Block, MD The Annals of Thoracic Surgery

Visceral Pleural Invasion Is Not a Significant Prognostic Factor in Patients With a Part- Solid Lung Cancer Aritoshi Hattori, MD, Kenji Suzuki, MD, Takeshi.

Induction Chemoradiation Is Not Superior to Induction Chemotherapy Alone in Stage IIIA Lung Cancer Asad A. Shah, MD, Mark F. Berry, MD, Ching Tzao, MD,

Meghan R. Flanagan, MD, Thomas K. Varghese, MD, MS, Leah M

Presentation transcript:

Challenges in Predicting Recurrence After Resection of Node-Negative Non-Small Cell Lung Cancer Lucas W. Thornblade, MD, MPH, Michael S. Mulligan, MD, Katherine Odem-Davis, PhD, Billanna Hwang, MPH, DHSc, Rachel L. Waworuntu, BS, Erika M. Wolff, PhD, Larry Kessler, ScD, Douglas E. Wood, MD, Farhood Farjah, MD, MPH The Annals of Thoracic Surgery Volume 106, Issue 5, Pages 1460-1467 (November 2018) DOI: 10.1016/j.athoracsur.2018.06.022 Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Diagram of cohort selection. (LCBRN = Lung Cancer Biospecimen Resource Network.) The Annals of Thoracic Surgery 2018 106, 1460-1467DOI: (10.1016/j.athoracsur.2018.06.022) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Kaplan-Meier survival estimates for recurrence-free survival among patients with completely resected, node-negative non-small cell lung cancer and for five pre-specified clinical risk-factors: (B) tumor size, (C) lymphovascular invasion (LVI), (D) visceral pleural invasion (VPI), (E) tumor grade, and (F) sublobar resection. The Annals of Thoracic Surgery 2018 106, 1460-1467DOI: (10.1016/j.athoracsur.2018.06.022) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Receiver operating characteristic curves (left) and calibration plots (right) for (A) model A (visceral pleural invasion, lymphovascular invasion, log-tumor size, tumor grade, and sublobar resection and (B) model B (model A plus vascular endothelial growth factor C, microRNA [miR]-486, and miR-30d). The time-dependent receiver operating characteristic curve was evaluated at 2 years using nearest neighbor estimator smoothing with a span equal to 0.25 × n–0.2, with n equal to the number of patients. The calibration plot reflects “predicted” survival probabilities at 24 months (recurrence-free survival) and corresponding “observed” survival probabilities by Kaplan-Meier (fraction recurrence-free at 24 months). The tick marks at the top of this figure indicate points observed with corresponding predicted survival. (AUC = area under the receiver operating characteristic curve; CI = confidence interval.) The Annals of Thoracic Surgery 2018 106, 1460-1467DOI: (10.1016/j.athoracsur.2018.06.022) Copyright © 2018 The Society of Thoracic Surgeons Terms and Conditions