Lipopolysaccharide Stimulation of Human Aortic Valve Interstitial Cells Activates Inflammation and Osteogenesis Ashok N. Babu, MD, Xianzhong Meng, MD,

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Presentation transcript:

Lipopolysaccharide Stimulation of Human Aortic Valve Interstitial Cells Activates Inflammation and Osteogenesis Ashok N. Babu, MD, Xianzhong Meng, MD, PhD, Ning Zou, MD, Xiaoping Yang, PhD, Maorong Wang, MD, Yong Song, MD, Joseph C. Cleveland, MD, Michael Weyant, MD, Anirban Banerjee, PhD, David A. Fullerton, MD The Annals of Thoracic Surgery Volume 86, Issue 1, Pages 71-76 (July 2008) DOI: 10.1016/j.athoracsur.2008.03.008 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Venn diagrams demonstrating extent of gene expression alteration resulting from treatment with lipopolysaccharide (LPS) and β-glycerol phosphate (BGP) at 4 hours and 24 hours. Altered genes were defined as those that were twofold increased or twofold decreased compared with controls. The Annals of Thoracic Surgery 2008 86, 71-76DOI: (10.1016/j.athoracsur.2008.03.008) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Interleukin (IL)-6 and IL-8 protein induced by lipopolysaccharide (LPS). The LPS stimulation induced significant increases in IL-6 and IL-8 protein levels at 24 hours. The Annals of Thoracic Surgery 2008 86, 71-76DOI: (10.1016/j.athoracsur.2008.03.008) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions