Volume 42, Issue 2, Pages 188-194 (February 2005) Long-term clinical and histological outcomes in patients with spontaneous hepatitis B surface antigen seroclearance  Sang Hoon Ahn, Young Nyun Park, Jun Yong Park, Hye-Young Chang, Jung Min Lee, Ji Eun Shin, Kwang-Hyub Han, Chanil Park, Young Myoung Moon, Chae Yoon Chon  Journal of Hepatology  Volume 42, Issue 2, Pages 188-194 (February 2005) DOI: 10.1016/j.jhep.2004.10.026 Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

Fig. 1 The time from baseline to the follow-up liver biopsy. The closed bars represent the period between the first and the follow-up liver biopsy. The time of HBeAg and HBsAg seroclearance are shown on the bars (▾, HBeAg seroclearance points; ▿, HBsAg seroclearance points). The duration from the time of HBeAg and HBsAg seroclearance to the time of the follow-up liver biopsy is shown at the right side of the figure. Liver biopsy specimens obtained at the end of follow-up were subjected to HBV DNA PCR and histological evaluation. Journal of Hepatology 2005 42, 188-194DOI: (10.1016/j.jhep.2004.10.026) Copyright © 2004 European Association for the Study of the Liver Terms and Conditions

Fig. 2 The first liver biopsy feature of patient 6 showing bridging necrosis and fibrosis (A, B). In second liver biopsy, the necroinflammatory activity is markedly decreased with occasional focal inflammation and apoptosis (C). Fibrosis is also decreased with portal expansion and short fibrous septa (D). (A, H–E ×40; B, C, H–E ×100; D, Masson's trichrome ×100). Journal of Hepatology 2005 42, 188-194DOI: (10.1016/j.jhep.2004.10.026) Copyright © 2004 European Association for the Study of the Liver Terms and Conditions