The role of fourth-generation cephalosporins in the treatment of infections caused by penicillin-resistant streptococci  Keith Klugman, Fred Goldstein,

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The role of fourth-generation cephalosporins in the treatment of infections caused by penicillin-resistant streptococci  Keith Klugman, Fred Goldstein, Shigeru Kohno, Fernando Baquero  Clinical Microbiology and Infection  Volume 3, Pages S48-S60 (April 1997) DOI: 10.1111/j.1469-0691.1997.tb00646.x Copyright © 1997 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 World-wide frequency of isolation of penicillin-resistant pneumococci (MIC > 0.12 mg/L, intermediate and high-level penicillin-resistant strains). Clinical Microbiology and Infection 1997 3, S48-S60DOI: (10.1111/j.1469-0691.1997.tb00646.x) Copyright © 1997 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 2 Effect of increasing the MIC values of penicillin on the 50% effective dose (ED50) in a S. pneumoniae peritonitis mouse model following penicillin treatment. From Knudsen et al. 50. With permission of Am Soc Microbiol J Div. Clinical Microbiology and Infection 1997 3, S48-S60DOI: (10.1111/j.1469-0691.1997.tb00646.x) Copyright © 1997 European Society of Clinical Infectious Diseases Terms and Conditions