Low-Dose Aspirin Affects the Small Bowel Mucosa: Results of a Pilot Study With a Multidimensional Assessment  Edgardo Smecuol, Maria Ines Pinto Sanchez, Alejandro Suarez, Julio E. Argonz, Emilia Sugai, Horacio Vazquez, Nestor Litwin, Elena Piazuelo, Jonathan B. Meddings, Julio C. Bai, Angel Lanas  Clinical Gastroenterology and Hepatology  Volume 7, Issue 5, Pages 524-529 (May 2009) DOI: 10.1016/j.cgh.2008.12.019 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Capsule endoscopic views of small bowel. (A, B) Petechiae and red spots (category 1); (C, D) mucosal erosion (category 2); (E) jejunal ulcer (category 4); (F) ileal ulcer (category 4). Clinical Gastroenterology and Hepatology 2009 7, 524-529DOI: (10.1016/j.cgh.2008.12.019) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Concentrations of fecal calprotectin in 20 healthy subjects at baseline and after 14 days of 100 mg/day enteric-coated ASA. Fecal calprotectin was increased after ASA administration; P < .0005 versus baseline values. The horizontal line indicates the upper normal limit (+2 standard deviations) for calprotectin concentrations. Clinical Gastroenterology and Hepatology 2009 7, 524-529DOI: (10.1016/j.cgh.2008.12.019) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Urinary excretion of intestinal permeability probes induced by ASA. Results illustrate urinary excretion of lac/man in 20 subjects at baseline and after 14 days of 100 mg/day enteric-coated ASA. Lac/man ratio was nonsignificantly increased after ASA administration; P < .08 versus baseline values. The horizontal line indicates the upper normal limit (+2 standard deviations) for lac/man ratio. Clinical Gastroenterology and Hepatology 2009 7, 524-529DOI: (10.1016/j.cgh.2008.12.019) Copyright © 2009 AGA Institute Terms and Conditions

Figure 4 Urinary excretion of gastroduodenal permeability probes induced by ASA. Results illustrate urinary excretion of sucrose in 20 subjects at baseline and after 14 days of 100 mg/day enteric-coated ASA. Fractional excretion of sucrose was increased after ASA administration; P < .05 versus baseline values. The horizontal line indicates the upper normal limit (+2 standard deviations) for sucrose urinary excretion. Clinical Gastroenterology and Hepatology 2009 7, 524-529DOI: (10.1016/j.cgh.2008.12.019) Copyright © 2009 AGA Institute Terms and Conditions