Fig. 6 Histomorphometrical evaluation of the segmental defect healing 24 weeks after surgery and quantification of mechanical strains. Histomorphometrical.

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Fig. 6 Histomorphometrical evaluation of the segmental defect healing 24 weeks after surgery and quantification of mechanical strains. Histomorphometrical evaluation of the segmental defect healing 24 weeks after surgery and quantification of mechanical strains. (A and B) The regions of interest (ROIs) within the FE model and the histological section were determined as a total 40-mm defect ROI (light blue rectangle), which was divided into a lateral (La) and a medial (Me) part, and a central ROI with a height of 10 mm (dark blue rectangle). Mid-sagittal thin section of a sample in the soft scaffold + LCP group 24 weeks after surgery (Safranin Orange/von Kossa staining). (C) Interquartile absolute maximum principal strains in the lateral and medial ROI of the soft and stiff scaffolds stabilized with an LCP. (D) The mineralized bone area in the medial and lateral ROI (in %; a dashed gray reference line marks the area filled with ABG during surgery = 7% ABG filling of the total ROI). (E) Interquartile absolute maximum principal strains in the central ROI for all groups. (F) The mineralized bone area in the central ROI. (G) Diagram showing the effect of stiffness (scaffold + plate fixation) and mechanical stimulation at the defect side on the bone regeneration response. (H) The cartilage area (as a measurement of endochondral ossification) in the total ROI (Mann-Whitney test, n = 6, P = 0.026). Anne-Marie Pobloth et al., Sci Transl Med 2018;10:eaam8828 Published by AAAS