Frequent Human Herpesvirus-6 Viremia But Low Incidence of Encephalitis in Double- Unit Cord Blood Recipients Transplanted Without Antithymocyte Globulin

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Frequent Human Herpesvirus-6 Viremia But Low Incidence of Encephalitis in Double- Unit Cord Blood Recipients Transplanted Without Antithymocyte Globulin Amanda L. Olson, Parastoo B. Dahi, Junting Zheng, Sean M. Devlin, Marissa Lubin, Anne Marie Gonzales, Sergio A. Giralt, Miguel- Angel Perales, Esperanza B. Papadopoulos, Doris M. Ponce, James W. Young, Nancy A. Kernan, Andromachi Scaradavou, Richard J. O’Reilly, Trudy N. Small, Genovefa Papanicolaou, Juliet N. Barker Biology of Blood and Marrow Transplantation Volume 20, Issue 6, Pages 787-793 (June 2014) DOI: 10.1016/j.bbmt.2014.02.010 Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 The incidence and severity of HHV-6 viremia in the first 100 days after CBT (N = 125) Nearly all patients reactivated, 77% ≥ 1000, but only 6% > 100,000 and none ≥ 1,000,000. Biology of Blood and Marrow Transplantation 2014 20, 787-793DOI: (10.1016/j.bbmt.2014.02.010) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Relationship between HHV-6 viral load and absolute lymphocyte (ALC) recovery after CBT. There was a significant association between absolute lymphocyte recovery (measured in K/μL) and resolution of HHV-6 viremia. The HHV-6 viral load in the first 60 days post-CBT is shown in black circles and ALC recovery is shown in red stars (all values for all patients). The solid lines are splines over time for HHV-6 viremia (black) and ALC recovery (red), respectively. Biology of Blood and Marrow Transplantation 2014 20, 787-793DOI: (10.1016/j.bbmt.2014.02.010) Copyright © 2014 American Society for Blood and Marrow Transplantation Terms and Conditions