Highly variable VDJβ gene usage in lupus-prone CD8+ T cells.

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Highly variable VDJβ gene usage in lupus-prone CD8+ T cells. Highly variable VDJβ gene usage in lupus-prone CD8+ T cells. (A–C) Vβ gene (A) usage for CD8+ T cells from wild type B6 spleen and TLR7tg spleen and brain. Equivalent IMGT and original (orig.) nomenclature for Vβ genes included. ps, pseudogene. (B) Dβ gene and (C) Jβ gene usage shown as in (A). Bars indicate minimum and maximum values centered on the mean. (D) Statistical analysis of discovered significant differences between indicated groups for (A–C). Multiple t test grouped analysis used to generate p values and false discovery rate–adjusted q values. These results are presented with two forms of nomenclature: the comprehensive international IMGT, and the original, still commonly used nomenclature. Peter A. Morawski, and Silvia Bolland ImmunoHorizons 2019;3:61-70 ©2019 by American Association of Immunologists