Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis J.J. McDougall, N. Schuelert, J. Bowyer

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Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis J.J. McDougall, N. Schuelert, J. Bowyer Osteoarthritis and Cartilage Volume 18, Issue 10, Pages 1355-1357 (October 2010) DOI: 10.1016/j.joca.2010.07.014 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Effect of acutely administered AZ12606133 on knee joint afferent firing rate in response to hyper-rotation of the knee. Blockade of cathepsin K had no effect on OA joint mechanosensitivity during this time period. Data are means and 95% confidence intervals. n=6–11 fibres. Osteoarthritis and Cartilage 2010 18, 1355-1357DOI: (10.1016/j.joca.2010.07.014) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions