Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania Xiangdong Wang, MD, PhD,

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Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania Xiangdong Wang, MD, PhD, Nan Zhang, MD, PhD, Mingyu Bo, MS, Gabriele Holtappels, Ming Zheng, MD, PhD, Hongfei Lou, MD, PhD, Hong Wang, BS, Luo Zhang, MD, PhD, Claus Bachert, MD, PhD Journal of Allergy and Clinical Immunology Volume 138, Issue 5, Pages 1344-1353 (November 2016) DOI: 10.1016/j.jaci.2016.05.041 Copyright © 2016 The Authors Terms and Conditions

Fig 1 World map with locations of the 6 centers and numbers of patients included in the study. Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig 2 Multiple correspondence analyses plot for the interrelationships between CRSwNP, CRSsNP, and control phenotypes and positive/negative protein expressions for the cytokines IL-5, IL-17, and IFN-γ (all regions A); and interrelationships between the 6 regions and IL-5, IL-17 and IFN-γ protein expressions for the CRSwNP phenotype (B). Distance between variables (phenotype and cytokine or region and cytokine) indicates the approximate relationship between variables. Thus the nearer they are located together, the stronger the relationship. Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig 3 Concentrations of IL-5 (A), IL-17 (B), IFN-γ (C), ECP (D), IL-8 (E), and tissue total IgE (F) in control subjects, patients with CRSsNP, and patients with CRSwNP. Data were not available for IL-8 in samples from patients in Adelaide. Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig 4 Patterns of TH1/TH2/TH17 cytokine expression in samples from patients with CRSwNP: Benelux (A), Berlin (B), Adelaide (C), Beijing (D), Chengdu (E), and Tochigi (F). Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig 5 Patterns of TH1/TH2/TH17 cytokine expression in samples from patients with CRSsNP (only 7 cases of CRSsNP in Tochigi, data not shown): Benelux (A), Berlin (B), Adelaide (C), Beijing (D), and Chengdu (E). Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig 6 Percentages of positive samples for tissue-specific IgE to SEs in patients with CRSwNP in different regions. ▵P = .001 and *P < .001). Data were not available for SE-specific IgE in samples from patients in Berlin. Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig 7 Percentage of the samples with eosinophilic (ECP/MPO ratio >1) and noneosinophilic (ECP/MPO ratio <1) phenotypes. Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig E1A Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig E1B Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig E1C Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig E1D Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig E1E Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions

Fig E1F Journal of Allergy and Clinical Immunology 2016 138, 1344-1353DOI: (10.1016/j.jaci.2016.05.041) Copyright © 2016 The Authors Terms and Conditions