The role of WNT signaling in sprouting angiogenesis.

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The role of WNT signaling in sprouting angiogenesis. The role of WNT signaling in sprouting angiogenesis. In this process, tip cells provide directional cues to the sprout cells that can proliferate and initiate the formation of a new vessel. WNT signaling can contribute to the proliferation and tube formation of the stalk cells. The effect of WNT signaling on the tip cells is likely to be indirect via the expression of delta-like ligand-4 (Dll4) in the stalk cells, which activates Notch signaling in the tip cells. Sébastien Foulquier et al. Pharmacol Rev 2018;70:68-141 Copyright © 2017 by The Author(s)‏