Volume 3, Issue 6, Pages (June 2006)

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Volume 3, Issue 6, Pages 387-388 (June 2006) CAT in the HAT: Catabolic inhibition by the histone acetyltransferase GCN5 Yi Liu, Marc Montminy Cell Metabolism Volume 3, Issue 6, Pages 387-388 (June 2006) DOI: 10.1016/j.cmet.2006.05.006 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 SIRT1 integrates nutrient and hormonal cues to modulate induction of the gluconeogenic program During fasting, pancreatic glucagon stimulates expression of PGC-1α in the liver. Elevations in gluconeogenic precursors like pyruvate promote accumulation of SIRT1 protein, which in turn triggers induction of gluconeogenic genes by catalyzing the NAD+-dependent deacetylation of PGC-1α. Cell Metabolism 2006 3, 387-388DOI: (10.1016/j.cmet.2006.05.006) Copyright © 2006 Elsevier Inc. Terms and Conditions