Not So Lonely at the Top for Cancer Stem Cells

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Presentation transcript:

Not So Lonely at the Top for Cancer Stem Cells Ann Zeuner, Ruggero De Maria Cell Stem Cell Volume 9, Issue 4, Pages 289-290 (October 2011) DOI: 10.1016/j.stem.2011.09.006 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Hierarchy of Colon Cancer Cells Colon tumors contain a small population of CSCs capable of self-renewal that are present in primary tumors (long-term tumor initiating cells, or LT-TICs) or show up only in subsequent transplants (delayed-contributing tumor initiating cells, or DC-TICs). Tumor transient-amplifying cells (T-TACs) generate the majority of cells in primary tumors, whereas the bulk of nontumorigenic cancer cells contribute little to tumor growth. Cell Stem Cell 2011 9, 289-290DOI: (10.1016/j.stem.2011.09.006) Copyright © 2011 Elsevier Inc. Terms and Conditions