The Use of Experimental Murine Models to Assess Novel Agents of Hematopoietic Stem and Progenitor Cell Mobilization Kirsten E. Herbert, Jean-Pierre Lévesque,

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The Use of Experimental Murine Models to Assess Novel Agents of Hematopoietic Stem and Progenitor Cell Mobilization Kirsten E. Herbert, Jean-Pierre Lévesque, David N. Haylock, Miles Prince Biology of Blood and Marrow Transplantation Volume 14, Issue 6, Pages 603-621 (June 2008) DOI: 10.1016/j.bbmt.2008.02.003 Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Hematopoietic lineage and assays of hematopoietic stem and progenitor cells (HSPC). HSC, hematopoietic stem cell; CRU, competitive repopulating unit; Hu-SCID, human cell into severe combined immune deficiency (mouse model); LTC-IC, long-term culture-initiating cell; CAFC, cobblestone area forming cell; HPP-CFC, high proliferative potential colony-forming cell; CFU-S, colony forming unit-spleen; CLP, common lymphoid progenitor; CMP, common myeloid progenitor; CFU-GEMM, colony-forming unit-granulocyte erythrocyte macrophage megakaryocyte; GMP, granulocyte macrophage progenitor; MEP, megakaryocyte erythroid progenitor; CFU-GM, colony-forming unit-granulocyte macrophage; CFU-M, colony-forming unit-macrophage; CFU-G-CSF, colony-forming unit-granulocyte; CFU-E, colony-forming unit-erythroid; BFU-E, burst-forming unit-erythroid; CFU-Meg, colony-forming unit-megakaryocyte. Biology of Blood and Marrow Transplantation 2008 14, 603-621DOI: (10.1016/j.bbmt.2008.02.003) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Murine spleen showing normal spleen (above) and macroscopic colony forming units-spleen (CFU-S) on the splenic surface, at day 12 posttransplant (below). (Photo courtesy of Dr. Stewart Fabb PhD, Barwon Biomedical Research, Geelong, Australia.) Biology of Blood and Marrow Transplantation 2008 14, 603-621DOI: (10.1016/j.bbmt.2008.02.003) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Possible schema for investigation of a novel agent for HSPC mobilization. Biology of Blood and Marrow Transplantation 2008 14, 603-621DOI: (10.1016/j.bbmt.2008.02.003) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions