Volume 377, Issue 9768, Pages (March 2011)

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Volume 377, Issue 9768, Pages 823-836 (March 2011) Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomised trial Prof PD White, MD, KA Goldsmith, MPH, AL Johnson, PhD, L Potts, MSc, R Walwyn, MSc, JC DeCesare, BSc, HL Baber, BSc, M Burgess, PhD, LV Clark, PhD, DL Cox, PhD, J Bavinton, BSc, BJ Angus, MD, G Murphy, MSc, M Murphy, FRCP, H O'Dowd, PhD, D Wilks, FRCP[Ed], Prof P McCrone, PhD, Prof T Chalder, PhD, Prof M Sharpe, MD The Lancet Volume 377, Issue 9768, Pages 823-836 (March 2011) DOI: 10.1016/S0140-6736(11)60096-2 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 CONSORT trial profile CFS=chronic fatigue syndrome. APT=adaptive pacing therapy. CBT=cognitive behaviour therapy. GET=graded exercise therapy. SMC=specialist medical care alone. The numbers of participants per centre ranged from 63 to 135. The Lancet 2011 377, 823-836DOI: (10.1016/S0140-6736(11)60096-2) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 2 Physical function subscale and fatigue questionnaire scores by treatment group Data are unadjusted means (95% CI). pinteraction is the p-value of the interaction between treatment and criteria or disorder from the adjusted model. CFS=chronic fatigue syndrome. ME=myalgic encephalomyelitis. (A–D) Lowest fatigue score is best. (E–H) Highest physical function score is best. The Lancet 2011 377, 823-836DOI: (10.1016/S0140-6736(11)60096-2) Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 3 Primary outcome treatment differences for fatigue (A) and physical function (B) at 52 weeks (A) Negative values for fatigue favour the first treatment group in each pair of comparisons. (B) Positive values for physical function favour the first treatment group in each pair of comparisons. APT=adaptive pacing therapy. SMC=specialist medical care. CBT=cognitive behaviour therapy. GET=graded exercise therapy. The Lancet 2011 377, 823-836DOI: (10.1016/S0140-6736(11)60096-2) Copyright © 2011 Elsevier Ltd Terms and Conditions