Pairwise gene-protein association analysis on CSF proteomics in the ADNI-1 cohort  Sungeun Kim, Shanker Swaminathan, Kwangsik Ngo, Shannon Risacher, Li.

Slides:



Advertisements
Similar presentations
How Do Thermophilic Proteins and Proteomes Withstand High Temperature? Lucas Sawle, Kingshuk Ghosh Biophysical Journal Volume 101, Issue 1, Pages
Advertisements

Counter-Intuitive Stochastic Behavior of Simple Gene Circuits with Negative Feedback Tatiana T. Marquez-Lago, Jörg Stelling Biophysical Journal Volume.
Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.
Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.
2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.
Sleep disruption changes across the disease trajectory: Pilot findings from the healthy patterns sleep study Nancy A. Hodgson, Albert J. Safi Alzheimer's.
Capillary dysfunction in Alzheimer's disease
DIAGNOSTIC ACCURACY AND CONFIDENCE IN THE CLINICAL DETECTION OF COGNITIVE IMPAIRMENT IN EARLY-STAGE PARKINSON’S DISEASE  Kathryn A. Wyman-Chick, Phillip.
Vladimir S. Fonov, Mahsa Dadar, Xiao Yiming, D. Louis Collins 
Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene- dependent?  Kirsi Kinnunen, Natalie Ryan, David Cash, António Bastos.
Relationship between Microstructural Degeneration of the Corpus Callosum, White Matter Hyperintensities, and Motor Function in Cognitively Intact Elderly 
Hilkka Liedes, Jyrki Lötjönen, Gerald P. Novak, Mark Forrest Gordon 
Comparison of accelerated and nonaccelerated MRI in ADNI: Effects on measures of brain and ventricular volumes and rates of atrophy  Kelvin Leung, Casper.
MTL SUBREGIONAL MORPHOMETRY USING HIGH RESOLUTION MRI IN ADNI2
A SYSTEMATIC REVIEW AND META-ANALYSIS COMPARING QUALITY-OF-LIFE RATINGS FROM FAMILY AND PAID CAREGIVERS OF PEOPLE WITH DEMENTIA RESIDING IN CARE HOMES 
Mutation frequency of pathogenic genes in familial Alzheimer’s disease in China  Jianping Jia, Liyong Wu, Wei Qin, Dan Li, Luxi Shen, Hanzhi Li, Qianqian.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Trajectory of multi-dimensional caregiving burden in chinese informal caregivers for dementia: Evidence from exploratory and confirmatory factor analysis.
Interaction network of tau protein, beta-amyloid protein, and amyloid protein precursor under oxidative stress in Alzheimer’s disease  Eduardo de Souza/S.
INCREASED CSF LEVELS OF BIOMARKERS FOR NEURODEGENERATION IN FTLD-GRN MUTATION CARRIERS  Joery Goossens, Sara Van Mossevelde, Tobi Van den Bossche, Anne.
SERUM NEUROFILAMENT LIGHT PROTEIN PREDICTS CLINICAL OUTCOME IN TRAUMATIC BRAIN INJURY  Pashtun Shahim, Magnus Gren, Victor Liman, Ulf Andreasson, Niklas.
The differential diagnosis of amnestic mild cognitive impairment and Alzheimer's disease dementia by hippocampal volume measurement with MR in a chinese.
Localization of Hippocampal atrophy in Alzheimer's disease
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Christine Bredfeldt, Kristen Rice, Lisa Alecxih 
CANDIDATE GENE STUDIES AND GWAS SUGGEST SUBSTANTIAL GENETIC INFLUENCE ON DEFICITS IN OLFACTORY IDENTIFICATION AMONG PERSONS AT RISK OF AD  Marie-Elyse.
KETOGENIC DIET EFFECTS ON BRAIN KETONE METABOLISM AND ALZHEIMER'S DISEASE CSF BIOMARKERS  Suzanne Craft, Bryan J. Neth, Akiva Mintz, Kiran Sai, Nora Shively,
The effect of using a conditional discrimination procedure to teach name-face relation to a person diagnosed with dementia  Hanna S. Steingrimsdottir,
Application of Resource Utilization in Dementia (RUD) instrument in a global setting  Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.
LATENT-FACTOR STRUCTURE OF THE DELCODE STUDY NEUROPSYCHOLOGICAL TEST BATTERY  Steffen Wolfsgruber, Luca Kleineidam, Jannis Guski, Oliver Peters, Katharina.
HYPERGLYCEMIA: PREDISPOSITION FOR MICROEMBOLI, STROKE, AND WHITE MATTER CHANGES  Leila Parand, Saif Bushnaq, Yue Wang, Lenora Mathes, Dinesh Jillella,
Marjolein Bulk, Linda van der Graaf, Walid M
Colin Groot, Chris W. J. van der Weijden, Wiesje M
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Japanese brain bank network for neuroscience research
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
BIOLOGICAL PATHWAYS FOUND IN COMMON BETWEEN ALZHEIMER’S DISEASE AND MAJOR DEPRESSION: A STUDY ON MICRORNA EXPRESSION IN A SYSTEMATIC REVIEW  Ana Paula.
Genetic Landscape of Eurasia and “Admixture” in Uyghurs
Community environment and incident dementia: Results from the three-city study  Claudine Berr, Laure Anne Gutierrez, Sylvaine Artero, Catherine Helmer,
Effect of hypertension and antihypertensive medication on executive function, brain atrophy, and white matter hyperintensities  Shannon L. Risacher, Li.
Application of Resource Utilization in Dementia (RUD) instrument in a global setting  Anders Wimo, Anders Gustavsson, Linus Jönsson, Bengt Winblad, Ming-Ann.
The SNP Endgame: A Multidisciplinary Approach*
LIFESPAN OF ONE FOCUSED ULTRASOUND MEDIATED BLOOD-BRAIN BARRIER TREATMENT IN A MOUSE MODEL OF ALZHEIMER'S DISEASE  Charissa Poon, Kullervo Hynynen  Alzheimer's.
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective  Matthew Baumgart, Heather M. Snyder,
LINKING GENE PATHWAYS AND BRAIN ATROPHY IN ALZHEIMER'S DISEASE
Shruti Mishra, Brian Andrew Gordon, Karl A
Comparison of visual and quantitative florbetapir-PET reads in subjects with early Alzheimer's disease for assessing amyloid burden  Bradley Wyman, Yahong.
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome Screen to Identify Susceptibility Genes for Parkinson Disease in a Sample without parkin Mutations  Nathan Pankratz, William C. Nichols, Sean K.
The incremental diagnostic value of 18F-florbetapir imaging in naturalistic patients with cognitive impairment: The India-FBP study  Marina Boccardi,
Added value of 11C-PiB-PET imaging in the diagnosis of Alzheimer's disease  Kristian Frederiksen, Anne-Mette Hejl, Ian Law, Steen Hasselbalch, Gunhild.
Mark D. Meadowcroft, Douglas G. Peters, Carson J
Effects of traumatic brain injury and posttraumatic stress disorder on Alzheimer's disease in veterans, using the Alzheimer's Disease Neuroimaging Initiative 
COGNITIVE COMPLAINTS IN OLDER ADULTS AT RISK FOR ALZHEIMER’S DISEASE ARE ASSOCIATED WITH ALTERED RESTING STATE NETWORKS  Joey A. Contreras, Joaquín Goñi,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Distinct [18F]AV1451 retention patterns in clinical variants of Alzheimer’s disease  Rik Ossenkoppele, Daniel Schonhaut, Suzanne Baker, Andreas Lazaris,
MR-less cortical surface-projection of PET images from 11C- and 18F-labeled radiotracers  Vincent Doré, Pierrick Bourgeat, Luping Zhou, Jurgen Fripp,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
DIFFERENCES IN ANALYTICAL SELECTIVITY OF β-AMYLOID (1-42) IMMUNOASSAYS EXPLAIN DISCORDANT RESULTS IN STUDY COMPARISONS  Hugo Marcel Vanderstichele, Emeric.
Alzheimer's Association towards Guidelines for Dementia Care Practice: Recommendations with emphasis on high-quality, person-centered care in long-term.
Brain amyloid deposition and metabolism in early and late mild cognitive impairment  Jared Rowley, Liyong Wu, Sara Mohades, Marina Dauar, Antoine Leuzy,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
INTRINSIC CONNECTIVITY NETWORKS IN POSTERIOR CORTICAL ATROPHY: A ROLE FOR THE PULVINAR?  Carolyn A. Fredericks, Jesse Brown, Jersey Deng, Rik Ossenkoppele,
Extracting white matter hyperintensities in Alzheimer's disease risk and aging studies using supervised segmentation methods  Vamsi Ithapu, Vikas Singh,
BRAIN AMYLOIDOSIS AND COGNITIVE DECLINE IN MCI: 12-MONTH FOLLOW-UP
Replication and meta-analysis of the CHRFAM7A copy number variant in a cohort of clinically characterized and neuropathologically verified individuals 
Michael Navitsky, Abhinay D. Joshi, Michael D. Devous, Michael J
ONE-YEAR GLOBAL OUTCOME OF A COMPREHENSIVE, INDIVIDUALIZED, PERSON CENTERED MANAGEMENT (CI-PCM) PROGRAM + MEMANTINE IN ADVANCED AD: A RANDOMIZED CONTROLLED.
Bistra Iordanova, Matthew C. Murphy, William E. Klunk, Alberto L
CSF biomarkers of Alzheimer's disease concord with amyloid-β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER.
Presentation transcript:

Pairwise gene-protein association analysis on CSF proteomics in the ADNI-1 cohort  Sungeun Kim, Shanker Swaminathan, Kwangsik Ngo, Shannon Risacher, Li Shen, Tatiana Foroud, Leslie Shaw, John Trojanowski, Michael Weiner, Andrew Saykin  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 8, Issue 4, Pages P41-P42 (July 2012) DOI: 10.1016/j.jalz.2012.05.102 Copyright © 2012 Terms and Conditions

Figure 1 Heatmap of significant associations at P <1.0×10−4 (upper) in the result of model 1 (M1) and linkage disequlibrium among significant SNPs within each gene. The heatmap shows the significant associations, not representing their p-values. The genetic model with smallest p-value for each association is represented by color and SNPs in a blue rectangle were also significantly associated with the same plasma analyte in ADNI-1 cohort. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2012 8, P41-P42DOI: (10.1016/j.jalz.2012.05.102) Copyright © 2012 Terms and Conditions