An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis

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An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis Amy L. Woodward, MD, Jonathan M. Spergel, MD, PhD, Harri Alenius, PhD, Emiko Mizoguchi, MD, PhD, Atul K. Bhan, MD, Emanuela Castigli, PhD, Scott R. Brodeur, PhD, Hans C. Oettgen, MD, PhD, Raif S. Geha, MD Journal of Allergy and Clinical Immunology Volume 107, Issue 2, Pages 359-366 (February 2001) DOI: 10.1067/mai.2001.112695 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Histologic features of saline-sensitized and OVA-sensitized skin sites in RAG2–/– and CD40–/– mice compared with their WT (129Sv × C57BL/6) controls. Skin sections were stained with standard hematoxylin-eosin. Magnification for large panels: 400×; small panels: 600×. Arrows indicate eosinophils. RAG2–/– mice do not exhibit an increase in dermal eosinophils and total cellular infiltrate after OVA sensitization, as is seen in WT mice. CD40–/– mice exhibit an increase in dermal eosinophils and total cellular infiltrate after OVA sensitization comparable to that observed in WT mice. Journal of Allergy and Clinical Immunology 2001 107, 359-366DOI: (10.1067/mai.2001.112695) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Histologic features and IL-4 mRNA expression in saline- and OVA-sensitized skin sites from RAG2–/–, IgH–/–, and WT control mice. A, Eosinophils/HPF at 1000× magnification. B, Infiltrating mononuclear cells/HPF at 1000× magnification. Mean values from 10 to 20 HPFs per animal are shown (n = 4-8 animals per strain). C, IL-4 mRNA levels as a ratio of IL-4 cDNA to cDNA of the constitutively expressed β2-microglobulin. Columns and bars represent mean values ± SE (n = 4-8 animals per strain). *P < .05. Journal of Allergy and Clinical Immunology 2001 107, 359-366DOI: (10.1067/mai.2001.112695) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 3 Histologic features of saline-sensitized and OVA-sensitized skin sites in IgH–/–, TCRα–/–, and TCRδ–/– mice compared with their WT (C57BL/6) controls. Skin sections were stained with standard hematoxylin-eosin. Magnification for large panels: 400×; small panels: 600×. Arrows indicate eosinophils. IgH–/– mice and TCRδ–/– mice exhibit an increase in dermal eosinophils and total cellular infiltrate after OVA sensitization comparable to that observed in WT mice. TCRα–/– mice do not exhibit an increase in dermal eosinophils and total cellular infiltrate after OVA sensitization, as is seen in WT mice. Journal of Allergy and Clinical Immunology 2001 107, 359-366DOI: (10.1067/mai.2001.112695) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 4 Histologic features and IL-4 mRNA expression in saline- and OVA-sensitized skin sites from TCRαβ–/– and TCRγδ–/– mice compared with WT controls. Sections are stained with hematoxylin-eosin. A, Eosinophils/HPF at ×1000 magnification. B, Infiltrating mononuclear cells/HPF at ×1000 magnification. C, IL-4 mRNA levels. Columns and bars represent mean values ± SE (n = 4-8 animals per strain). *P < .05. Journal of Allergy and Clinical Immunology 2001 107, 359-366DOI: (10.1067/mai.2001.112695) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 5 Serum IgE levels (A) and serum IgE anti-OVA (B) in TCRαβ–/– and TCRγδ–/– and WT controls. Columns and bars represent mean values ± SE (n = 4-8 animals per strain). *P < .05. Journal of Allergy and Clinical Immunology 2001 107, 359-366DOI: (10.1067/mai.2001.112695) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 6 Histologic features and IL-4 mRNA levels of and OVAsensitized skin sites from CD40–/– mice and WT controls. A, Eosinophils/HPF at ×1000 magnification. B, Infiltrating mononuclear cells/HPF at ×1000 magnification. C, IL-4 mRNA levels. Columns and bars represent mean values ± SE (n = 4-8 animals per strain). *P < .05. Journal of Allergy and Clinical Immunology 2001 107, 359-366DOI: (10.1067/mai.2001.112695) Copyright © 2001 Mosby, Inc. Terms and Conditions