Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD

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Presentation transcript:

IL-13/IL-22–coproducing T cells, a novel subset, are increased in atopic dermatitis Yuichi Teraki, MD, Aika Sakurai, MD, Seiichi Izaki, MD Journal of Allergy and Clinical Immunology Volume 132, Issue 4, Pages 971-974 (October 2013) DOI: 10.1016/j.jaci.2013.07.029 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Percentage of cytokine-producing T cells among circulating CD4+ and CD8+ populations in patients with AD (n = 13), patients with psoriasis (n = 10), and healthy subjects (n = 9). B, Representative FACS plots for patients with AD. C, Proportions of IL-22–producing CD4+ and CD8+ T cells that coexpress IL-4, IL-13, IL-17, or IFN-γ in patients with AD and psoriasis. Results are relative percentages, with the IL-22–producing cell population set at 100%. FACS, Fluorescence-activated cell sorting. Journal of Allergy and Clinical Immunology 2013 132, 971-974DOI: (10.1016/j.jaci.2013.07.029) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Percentage of cytokine-producing T cells among circulating CD4+ and CD8+ populations in patients with AD (n = 13), patients with psoriasis (n = 10), and healthy subjects (n = 9). B, Representative FACS plots for patients with AD. C, Proportions of IL-22–producing CD4+ and CD8+ T cells that coexpress IL-4, IL-13, IL-17, or IFN-γ in patients with AD and psoriasis. Results are relative percentages, with the IL-22–producing cell population set at 100%. FACS, Fluorescence-activated cell sorting. Journal of Allergy and Clinical Immunology 2013 132, 971-974DOI: (10.1016/j.jaci.2013.07.029) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 A, Correlations between the eosinophil counts and the percentages of IL-13/IL-22–coproducing CD4+ and CD8+ T cells in the circulation of patients with AD (n = 13). B, Comparison of the percentages of IL-13/IL-22–coproducing cells in the CLA+CCR4+ and CLA−CCR4− subsets among circulating CD4+ and CD8+ T cells in patients with AD. CLA, Cutaneous lymphocyte antigen; CCR4, CC chemokine receptor 4. Journal of Allergy and Clinical Immunology 2013 132, 971-974DOI: (10.1016/j.jaci.2013.07.029) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions