Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity Motohisa Tofukuji, MD, PhD, Alon Stamler,

Slides:

Advertisements

Similar presentations

Coronary Artery Bypass for Heart Failure in Ischemic Cardiomyopathy: 17-Year Follow- Up Marco Pocar, MD, PhD, Andrea Moneta, MD, Adalberto Grossi, MD,

Advertisements

Bone Morphogenic Protein-4 Contributes to Venous Endothelial Dysfunction in Patients With Diabetes Undergoing Coronary Revascularization Jia Hu, MD,

Hypercholesterolemia Impairs the Myocardial Angiogenic Response in a Swine Model of Chronic Ischemia: Role of Endostatin and Oxidative Stress Munir Boodhwani,

Altered coronary microvascular serotonin receptor expression after coronary artery bypass grafting with cardiopulmonary bypass Michael P. Robich, MD,

Heart preservation in HTK solution: role of coronary vasculature in recovery of cardiac function Yuhei Saitoh, MD, PhD, Michio Hashimoto, PhD, Kwansong.

Prolonged donor heart preservation with pinacidil: The role of mitochondria and the mitochondrial adenosine triphosphate–sensitive potassium channel

Gefeng Li, John A. Sullivan, John M. You, Richard I. Hall

Delivery of a nonpotassium modified maintenance solution to enhance myocardial protection in stressed neonatal hearts: A new approach Michael T. Kronon,

Coronary Bypass Grafting to a “Full-Metal Jacket” Left Anterior Descending Artery María J. Mataró, MD, Gemma Sánchez-Espín, MD, Carlos Porras, MD, José.

The role of cardioplegia induction temperature and amino acid enrichment in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD,

Regulation of Human Internal Mammary and Radial Artery Contraction by Extracellular and Intracellular Calcium Channels and Cyclic Adenosine 3′, 5′ Monophosphate

Superiority of magnesium cardioplegia in neonatal myocardial protection Michael T Kronon, MD, Bradley S Allen, MD, Janeen Hernan, MS, Ari O Halldorsson,

Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction Katsuhiko Nakanishi, MD,

Basal nitric oxide expresses endogenous cardioprotection during reperfusion by inhibition of neutrophil-mediated damage after surgical revascularization

Hypomagnesemia Inhibits Nitric Oxide Release From Coronary Endothelium: Protective Role of Magnesium Infusion After Cardiac Operations1 Paul J. Pearson,

Nonischemic myocardial acidosis adversely affects microvascular and myocardial function and triggers apoptosis during cardioplegia Kamal R. Khabbaz,

Improved profile of bad phosphorylation and caspase 3 activation after blood versus crystalloid cardioplegia Jun Feng, MD, PhD, Cesario Bianchi, MD,

Potassium Channel-Related Relaxation by Levosimendan in the Human Internal Mammary Artery Oguzhan Yildiz, MD, PhD, Melik Seyrek, MD, Vedat Yildirim,

Toshihiro Fukui, MD, Shuichiro Takanashi, MD, Yasuyuki Hosoda, MD

Hiroki Sato, James E Jordan, Zhi-Qing Zhao, S

Osamu Katayama, MD, Simon J

Snaring of the Target Vessel in Less Invasive Bypass Operations Does Not Cause Endothelial Dysfunction Louis P Perrault, Philippe Menasché, Jean-Pierre.

Surgical Resection of a Giant Coronary Aneurysm

Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia Ashraf A. Sabe, MD, Brittany.

Intracellular free calcium accumulation in ferret vascular smooth muscle during crystalloid and blood cardioplegic infusions Motohisa Tofukuji, MD, PhDa,

Poly-ADP-ribose polymerase inhibition protects against myocardial and endothelial reperfusion injury after hypothermic cardiac arrest Gábor Szabó, MD,

Continuous warm versus intermittent cold cardioplegic infusion: A comparison of energy metabolism, sodium-potassium adenosine triphosphatase activity,

Robert C King, MD, Victor E Laubach, PhD, R

Normokalemic adenosine–lidocaine cardioplegia: Importance of maintaining a polarized myocardium for optimal arrest and reanimation Kathryn L. Sloots,

The coronary artery bypass conduit: II

Coronary Microvascular Reactivity After Ischemic Cold Storage and Reperfusion Charles O Murphy, MD, Pan- Chih, MD, John Parker Gott, MD, Robert A Guyton,

Long Segmental Reconstruction of Diffusely Diseased Left Anterior Descending Coronary Artery With Left Internal Thoracic Artery With or Without Endarterectomy

Cardiopulmonary bypass, myocardial management, and support techniques Changes in autonomic response of the cerebral circulation after normothermic extracorporeal.

Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial.

Myocardial protection in normal and hypoxically stressed neonatal hearts: The superiority of hypocalcemic versus normocalcemic blood cardioplegia Kirk.

Coronary Artery Fistulae Involving Both Right and Left Coronary Arteries Ahmet Bolukcu, MD, Ahmet Can Topcu, MD, Yavuz Sensoz, MD, Ilyas Kayacioglu, MD

Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia Stacy B. O’Blenes, MD, Camille Hancock Friesen, MD,

Cardioplegia and vascular injury

Munir Boodhwani, MD, William E

Experimental study of intermittent crossclamping with fibrillation and myocardial protection: Reduced injury from shorter cumulative ischemia or intrinsic.

Ischemic preconditioning with opening of mitochondrial adenosine triphosphate– sensitive potassium channels or Na+/H+ exchange inhibition: Which is the.

Terje S. Larsen, PhD, Øivind Irtun, MD PhD, Terje K

Severe Two-Vessel Ostial Stenosis of the Main Coronary Arteries in a Patient With Transposition of the Great Arteries After an Arterial Switch Operation

Inhibition of Glycogen Synthase Kinase-3β Improves Tolerance to Ischemia in Hypertrophied Hearts Rodrigo Barillas, MD, MBA, Ingeborg Friehs, MD, Hung.

Sialyl LewisX oligosaccharide preserves cardiopulmonary and endothelial function after hypothermic circulatory arrest in lambs Marc L. Schermerhorn,

Ulinastatin attenuates reperfusion injury in the isolated blood-perfused rabbit heart Zhi-Li Cao, MD, Yukio Okazaki, MD, Kozo Naito, MD, Tetsuya Ueno,

Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest Ru Lin,

Preconditioning improves cardioplegia-related coronary microvascular smooth muscle hypercontractility: Role of KATP channels Naruto Matsuda, MD, PhDa,

Mesenteric dysfunction after cardiopulmonary bypass: role of complement C5a Motohisa Tofukuji, MD, PhD, Gregory L Stahl, PhD, Caroline Metais, MD, Mikio.

Adenosine-enhanced ischemic preconditioning provides myocardial protection equal to that of cold blood cardioplegia James D McCully, PhD, Masahisa Uematsu,

Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: Reversal by means.

Postischemic Function and Protein Kinase C Signal Transduction

Effect of sialyl Lewisx oligosaccharide on myocardial and cerebral injury in the pig Motohisa Tofukuji, MD, PhD, Caroline Metais, MD, Charles D Collard,

Polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia is equivalent to hypothermic potassium blood cardioplegia Joel S. Corvera,

Storage of radial artery grafts in blood increases vessel reactivity to vasoconstrictors in vitro James Tatoulis, Guang-Chi Jiang, PhD, James D Moffatt,

Intermittent Warm Blood Cardioplegia Preserves Myocardial β-Adrenergic Receptor Function Massimo Chello, Pasquale Mastroroberto, Vincenzo De Amicis,

Circumflex Coronary Artery From Right Pulmonary Artery in Hypoplastic Left Heart Syndrome Emmanuel Villa, MD, Gianluca Brancaccio, MD, Adriano Carotti,

Intermittent warm blood cardioplegia in the surgical treatment of congenital heart disease: Clinical experience with 1400 cases Yves Durandy, MD, Sylvie.

High-dose atorvastatin is associated with impaired myocardial angiogenesis in response to vascular endothelial growth factor in hypercholesterolemic swine

Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined.

“Transitions” for Cardiothoracic Surgeons Now Listed on the Web:

David J Chambers, PhD, David J Hearse, DSc

Håvard Nordgaard, MD, Nicola Vitale, MD, PhD, Rune Haaverstad, MD, PhD

Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor: Insight into ischemia-induced reduction in endothelium-dependent.

Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution Jeffrey M. Pearl,

Captopril in Cardioplegia and Reperfusion: Protective Effects on the Ischemic Heart Jacob Gurevitch, Dimitri Pevni, Inna Frolkis, Menachem Matsa, Yosi.

Amisha J. Patel, MD, Rahul M. Mehta, Divyakant B

Randy M. Stevens, MD, M. Salik Jahania, MD, Robert M

Effects of in vivo myocardial ischemia and reperfusion on interstitial nitric oxide metabolites Randy M Stevens, MD, M.Salik Jahania, MD, Jennifer E.

Erik Madssen, RF, Petter Haere, MD, Rune Wiseth, MD, PhD

Presentation transcript:

Comparative Effects of Continuous Warm Blood and Intermittent Cold Blood Cardioplegia on Coronary Reactivity Motohisa Tofukuji, MD, PhD, Alon Stamler, MD, Jianyi Li, MB, MS, Mukesh D. Hariawala, MD, Alvin Franklin, MS, Frank W. Sellke, MD The Annals of Thoracic Surgery Volume 64, Issue 5, Pages 1360-1367 (November 1997) DOI: 10.1016/S0003-4975(97)00990-9 Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 In vitro responses of precontracted porcine coronary microvessels to isoproterenol from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of relaxation of the acetylcholine-induced vascular contraction. (**p<0.01 versus control group.) The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 In vitro responses of precontracted porcine coronary microvessels to forskolin from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of the relaxation of the acetylcholine-induced vascular contraction. (*p<0.05 versus iCB-CP; **p<0.01 versus control and cWB-CP groups.) The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 In vitro responses of precontracted porcine coronary microvessels to 8-bromo-cyclic adenosine monophosphate (AMP) from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of the relaxation of the acetylcholine-induced vascular contraction. (*p<0.05 versus iCB-CP-Rep group.) The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 In vitro responses of precontracted porcine coronary microvessels to adenosine 5′-diphosphate (ADP) from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of the relaxation of the acetylcholine-induced vascular contraction. The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 In vitro responses of precontracted porcine coronary microvessels to the calcium ionophore A23187 from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of the relaxation of the acetylcholine-induced vascular contraction. The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 In vitro responses of precontracted porcine coronary microvessels to 8-bromo-cyclic guanosine monophosphate (GMP) from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of the relaxation of the acetylcholine-induced vascular contraction. (*p<0.05 versus control and cWB-CP groups; #p<0.05 versus cWB-CP-Rep group.) The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 7 In vitro responses of precontracted porcine coronary microvessels to sodium nitroprusside (SNP) from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of the relaxation of the acetylcholine-induced vascular contraction. The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 8 In vitro responses of precontracted porcine coronary microvessels to pinacidil from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Responses are expressed as the percentage of the relaxation of the acetylcholine-induced vascular contraction. The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 9 Plot showing (A) active and (B) passive pressure–diameter relationships in porcine coronary microvessels from control hearts, hearts after 1 hour of ischemic cardioplegic arrest using intermittent cold blood (iCB-CP) or continuous warm blood (cWB-CP) cardioplegic solution, or after ischemic arrest with either cardioplegia, followed by 1 hour of reperfusion (iCB-CP-Rep or cWB-CP-Rep). Passive pressure– diameter relationships were obtained after pretreatment of the vessels with 0.1mmol/L papaverine (Pap). Vessel diameters were normalized to diameters at a pressure of 50mm Hg after the application of 0.1mmol/L papaverine. (**p<0.01 control versus iCB-CP, iCB-CP-Rep, cWB-CP, and cWB-CP-Rep groups.) The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions

Fig 10 Plot showing (A) heart rate (HR), (B) mean systemic arterial pressure (MAP) and (C) blood flow of left anterior descending artery (LAD flow) at baseline and at 10, 20, 30, and 60 minutes after reperfusion using intermittent cold blood or continuous warm blood cardioplegic solution (iCB-CP-Rep or cWB-CP-Rep). (*p<0.05 versus iCB-CP-Rep group.) The Annals of Thoracic Surgery 1997 64, 1360-1367DOI: (10.1016/S0003-4975(97)00990-9) Copyright © 1997 The Society of Thoracic Surgeons Terms and Conditions