Measure Acute rejection Chronic allograft nephropathy

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Log-transformed mean (±SE) ratio of FOXP3 mRNA copies to 18S ribosomal RNA (rRNA) copies Measure Acute rejection Chronic allograft nephropathy Normal biopsy results Ratio of FOXP3 mRNA copies to 18S rRNA copies 3.8±0.5 1.3±0.7 1.6±0.4* *p<0.001 by Kruskal-Wallis test Muthukumar T et al. N Engl J Med 2005; 353:2342-2351.

Graft failure rate at six months after an episode of acute rejection by tertile of FOXP3 mRNA Group Graft-failure rate Relative risk Highest tertile (%) 8 — Middle tertile (%) 25 3.00 Lowest tertile (%) 50 6.00 Muthukumar T et al. N Engl J Med 2005; 353:2342-2351.