Hiroyuki Matsubayashi, Halcyon G

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Presentation transcript:

Pancreaticobiliary Cancers With Deficient Methylenetetrahydrofolate Reductase Genotypes Hiroyuki Matsubayashi, Halcyon G. Skinner, Christine Iacobuzio-donahue, Tadayoshi Abe, Norihiro Sato, Taylor Sohn Riall, Charles J. Yeo, Scott E. Kern, Michael Goggins Clinical Gastroenterology and Hepatology Volume 3, Issue 8, Pages 752-760 (August 2005) DOI: 10.1016/S1542-3565(05)00359-9 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Correlation between MTHFR 677 genotype and % of LINE1 methylation. The average of LINE1 methylation level was decreased from 677CC/C genotype (32.5% ± 10.3%), via 677CT (26.0% ± 8.9%) to 677TT/T (24.4% ± 8.5%). White circle, pancreatic cancer cell line; gray circle, breast cancer cell line; black, colon cancer cell line. *P = .014 by Kruskal-Wallis test. Clinical Gastroenterology and Hepatology 2005 3, 752-760DOI: (10.1016/S1542-3565(05)00359-9) Copyright © 2005 American Gastroenterological Association Terms and Conditions