Association Between Factor V Leiden Mutation, Small for Gestational Age, and Preterm Birth: A Systematic Review and Meta-Analysis Erin M. Hemsworth,

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Presentation transcript:

Association Between Factor V Leiden Mutation, Small for Gestational Age, and Preterm Birth: A Systematic Review and Meta-Analysis Erin M. Hemsworth, MD, MSc, Amanda M. O'Reilly, MD, Victoria M. Allen, MD, MSc, Stefan Kuhle, MD, MPH, PhD, Jo-Ann K. Brock, MD, PhD Prakesh Shah, Arne Ohlsson, Vibhuti Shah, Kellie E. Murphy, Sarah D. McDonald, Eileen Hutton, Corine Frick, Fran Scott, Victoria Allen, Joseph Beyene Erin M. Hemsworth, MD, MSc, Amanda M. O'Reilly, MD, Victoria M. Allen, MD, MSc, Stefan Kuhle, MD, MPH, PhD, Jo-Ann K. Brock, MD, PhD Prakesh Shah, Arne Ohlsson, Vibhuti Shah, Kellie E. Murphy, Sarah D. McDonald, Eileen Hutton, Corine Frick, Fran Scott, Victoria Allen, Joseph Beyene Journal of Obstetrics and Gynaecology Canada Volume 38, Issue 10, Pages 897-908 (October 2016) DOI: 10.1016/j.jogc.2016.08.001 Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada Terms and Conditions

Figure 1 Study selection process of systematic review using Medline, Embase, and CINAHL Journal of Obstetrics and Gynaecology Canada 2016 38, 897-908DOI: (10.1016/j.jogc.2016.08.001) Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada Terms and Conditions

Figure 2 Comparison of risk of SGA between pregnancies with factor V Leiden mutation and pregnancies without factor V Leiden mutation (all included studies) Journal of Obstetrics and Gynaecology Canada 2016 38, 897-908DOI: (10.1016/j.jogc.2016.08.001) Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada Terms and Conditions

Figure 3 Comparison of risk of SGA between pregnancies with factor V Leiden mutation and pregnancies without factor V Leiden mutation by study design Journal of Obstetrics and Gynaecology Canada 2016 38, 897-908DOI: (10.1016/j.jogc.2016.08.001) Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada Terms and Conditions

Figure 4 Comparison of risk of preterm birth between pregnancies with factor V Leiden mutation and pregnancies without factor V Leiden mutation (all included studies) Journal of Obstetrics and Gynaecology Canada 2016 38, 897-908DOI: (10.1016/j.jogc.2016.08.001) Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada Terms and Conditions

Figure 5 Comparison of risk of preterm birth between pregnancies with factor V Leiden mutation and pregnancies without factor V Leiden mutation by study design Journal of Obstetrics and Gynaecology Canada 2016 38, 897-908DOI: (10.1016/j.jogc.2016.08.001) Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada Terms and Conditions

Figure 6 Evaluation for publication bias in the included cohort and case-control studies associated with the outcomes of SGA and preterm birth using funnel plots. SE: standard error; PTB: preterm birth Journal of Obstetrics and Gynaecology Canada 2016 38, 897-908DOI: (10.1016/j.jogc.2016.08.001) Copyright © 2016 The Society of Obstetricians and Gynaecologists of Canada/La Société des obstétriciens et gynécologues du Canada Terms and Conditions