Primary cutaneous Epstein-Barr virus–related lymphoproliferative disorders in 4 immunosuppressed children Nadège Wallet-Faber, MD, Christine Bodemer,

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Primary cutaneous Epstein-Barr virus–related lymphoproliferative disorders in 4 immunosuppressed children Nadège Wallet-Faber, MD, Christine Bodemer, MD, Stéphane Blanche, MD, Eric Delabesse, MD, Catherine Eschard, MD, Nicole Brousse, MD, Sylvie Fraitag, MD Journal of the American Academy of Dermatology Volume 58, Issue 1, Pages 74-80 (January 2008) DOI: 10.1016/j.jaad.2007.08.013 Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Case 1. A, Infiltration of whole dermis by lymphocytes with large nuclei and ample cytoplasms. B, Intense staining for CD3, indicative of T-cell lineage. C, Cells containing Epstein-Barr virus–encoded small nuclear RNA demonstrated by in situ hybridization. D, Kaposiform lesion on left leg. (A to C, Hematoxylin-eosin stain; original magnifications: A and C, ×100; B, ×25.) Journal of the American Academy of Dermatology 2008 58, 74-80DOI: (10.1016/j.jaad.2007.08.013) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Case 2. Dense nodular and interstitial lymphoid infiltrate extending through whole dermis. (Hematoxylin-eosin stain; original magnification: ×100.) Journal of the American Academy of Dermatology 2008 58, 74-80DOI: (10.1016/j.jaad.2007.08.013) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Case 3. Dense large cell lymphoid infiltrate of subcutaneous tissue. (Hematoxylin-eosin stain; original magnification: ×200.) Journal of the American Academy of Dermatology 2008 58, 74-80DOI: (10.1016/j.jaad.2007.08.013) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Case 4. A, Ulceronecrotic vulvar lesion. B, Large lymphocytes with abundant cytoplasms and pleomorphic nuclei, and scanty reactive infiltrate of small lymphocytes. (Hematoxylin-eosin stain; original magnification: ×100.) Journal of the American Academy of Dermatology 2008 58, 74-80DOI: (10.1016/j.jaad.2007.08.013) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions