ACASI Questionnaire Schedule - Oral Visit Visit Code ACASI Questionnaire to administer Administer to: Enrollment 3.0 All participants enrolled Month 3* 6.0 First Quarterly Oral All participants randomized to oral arm (unless product continuously held/discontinued past 4 weeks) Months 6, 9, 15, 18, 21, 27, 30 9.0, 12.0, 18.0, 21.0, 24.0, 30.0, 33.0 Regular Quarterly Oral Months 12, 24, and PUEV/Early Termination 15.0, 27.0, visit code associated with study month when PUEV/Early Termination occurs** Annual/PUEV Oral All participants randomized to oral arm who are completing an annual visit, scheduled PUEV, or early termination visit (unless product continuously held/discontinued past 4 weeks) Study Exit (SEV) or any quarterly or semiannual visit where participant has been on continuous product hold/ discontinuation for the past 4 weeks 89.0, visit code associated with study month when quarterly or semiannual visit occurs** Product Hold/ Discontinuers/SEV Participants randomized to oral arm who are completing a scheduled SEV, who have had product continuously held by site staff for 4 weeks or more, or who have permanently discontinued study product (site or participant choice) 4 or more weeks ago * If participant misses her Month 3 Visit, administer the First Quarterly Oral ACASI questionnaire at the first quarterly visit she completes. **Refer to SSP Section Table 14-2 for the list of visit codes assigned to each study visit

ACASI Questionnaire Schedule - Vaginal Visit Visit Code ACASI Questionnaire to administer Administer to: Enrollment 3.0 All participants enrolled Month 3* 6.0 First Quarterly Vaginal All participants randomized to vaginal arm (unless product continuously held/discontinued past 4 weeks) Months 6, 9, 15, 18, 21, 27, 30 9.0, 12.0, 18.0, 21.0, 24.0, 30.0, 33.0 Regular Quarterly Vaginal Months 12, 24, and PUEV/Early Termination 15.0, 27.0, visit code associated with study month when PUEV/Early Termination occurs** Annual/PUEV Vaginal All participants randomized to vaginal arm who are completing an annual visit, scheduled PUEV, or early termination visit (unless product continuously held/discontinued past 4 weeks) Study Exit (SEV) or any quarterly or semiannual visit where participant has been on continuous product hold/ discontinuation for the past 4 weeks 89.0, visit code associated with study month when quarterly or semiannual visit occurs** Product Hold/ Discontinuers/SEV Participants randomized to vaginal arm who are completing a scheduled SEV, who have had product continuously held by site staff for 4 weeks or more, or who have permanently discontinued study product (site or participant choice) 4 or more weeks ago * If participant misses her Month 3 Visit, administer the First Quarterly Vaginal ACASI questionnaire at the first quarterly visit she completes. **Refer to SSP Section Table 14-2 for the list of visit codes assigned to each study visit