M.L. Delco Osteoarthritis and Cartilage

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Acute mitochondrial dysfunction in cartilage following mechanical injury M.L. Delco Osteoarthritis and Cartilage Volume 23, Pages A288-A289 (April 2015) DOI: 10.1016/j.joca.2015.02.525 Copyright © 2015 Terms and Conditions

Fig. 1. Experimental design Fig. 1. Experimental design. For the example microrespirometry plate layout, Hi = high impact, Lo = low impact, C = no impact, L = left limb R = right limb, BC = background [O2] correction wells. Osteoarthritis and Cartilage 2015 23, A288-A289DOI: (10.1016/j.joca.2015.02.525) Copyright © 2015 Terms and Conditions

Fig 2. Respirometry in injured cartilage. Data represents OCR over time. A) Impacted cartilage from the PFG (• = low impact, •= high impact) display lower basal OCRs (0-30 min) than controls (•) and an altered response after addition of oligomycin (O), FCCP (F), and rotenone/antimycin A (R+A). B) The same trends occur in the condyle (B) but basal OCRs are higher.• = control,• = low impact, • = high impact. • = background [O2] correction data. Osteoarthritis and Cartilage 2015 23, A288-A289DOI: (10.1016/j.joca.2015.02.525) Copyright © 2015 Terms and Conditions

Fig 3. Cartilage injury results in MT depolarization and cell death Fig 3. Cartilage injury results in MT depolarization and cell death. Confocal images of (A) control and (B) impacted cartilage stained with MitoTracker Green (green; all MT), TMRM (red; polarized MT only) and Hoechst 33342 (blue; nuclei). Green-only stained MT with increased uptake of nuclear stain indicates compromised integrity of both the cell and MT membranes. Calcein AM/ethidium homodimer (green/red; live/dead cell) staining of control (C) and impacted (D) explants. Osteoarthritis and Cartilage 2015 23, A288-A289DOI: (10.1016/j.joca.2015.02.525) Copyright © 2015 Terms and Conditions