Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population S. Maeda, N. Osawa, T. Hayashi, S. Tsukada, M.

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Presentation transcript:

Genetic variations associated with diabetic nephropathy and type II diabetes in a Japanese population S. Maeda, N. Osawa, T. Hayashi, S. Tsukada, M. Kobayashi, R. Kikkawa Kidney International Volume 72, Pages S43-S48 (August 2007) DOI: 10.1038/sj.ki.5002385 Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 1 Combinational effects by which RAS gene polymorphisms confer susceptibility to diabetic nephropathy.17 The upper table indicates the results of a step-wise logistic regression analysis. The lower panel indicates the increased odds ratio according to the number of risk genotypes. 95% CIs are indicated in parenthesis. Kidney International 2007 72, S43-S48DOI: (10.1038/sj.ki.5002385) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 2 The results of genome-wide screening for diabetic nephropathy using 94 nephropathy cases and 94 control subjects.19 Kidney International 2007 72, S43-S48DOI: (10.1038/sj.ki.5002385) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 3 LD mapping around the marker SNPs in the genome-wide screening. Data from the HapMap database for the Japanese are presented. (a) SLC12A3 locus at chromosome 16q13. *Marker SNP (rs2289116). (b) ELMO1 locus at chromosome 7p14. *Marker SNP (rs741301). Kidney International 2007 72, S43-S48DOI: (10.1038/sj.ki.5002385) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 4 The results of genome-wide screening for type II diabetes.23 (a) Results of the first and second tests. (b) Detailed result of the second test. *TFAP2B locus. Kidney International 2007 72, S43-S48DOI: (10.1038/sj.ki.5002385) Copyright © 2007 International Society of Nephrology Terms and Conditions

Figure 5 The TFAP2B locus at chromosome 6p12. Upper panel: LD mapping for this locus obtained from the HapMap database. Lower panel: structure of the TFAP2B gene. *Marker SNP (rs2076308). S-allele, disease susceptibility allele and N-allele, major allele. Kidney International 2007 72, S43-S48DOI: (10.1038/sj.ki.5002385) Copyright © 2007 International Society of Nephrology Terms and Conditions