Spectraplakins: The Cytoskeleton's Swiss Army Knife

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Spectraplakins: The Cytoskeleton's Swiss Army Knife Nicholas H. Brown Cell Volume 135, Issue 1, Pages 16-18 (October 2008) DOI: 10.1016/j.cell.2008.09.023 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 ACF7 Coordinates Actin and Microtubules in Cytoskeleton-Focal Adhesion Dynamics The spectraplakin ACF7 directly binds both microtubules and actin filaments and has an actin-dependent ATPase activity. In wild-type cells (left), ACF7 coordinates the targeting of microtubules to focal adhesions, where they direct disassembly of the adhesion contact and promote cell movement. ACF7-deficient cells (right) show altered microtubule organization accompanied by a loss of microtubule targeting to focal adhesions, which become stabilized and enlarged. Cell 2008 135, 16-18DOI: (10.1016/j.cell.2008.09.023) Copyright © 2008 Elsevier Inc. Terms and Conditions