M. Kim, J.A. Burdick, R.L. Mauck Osteoarthritis and Cartilage

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Age-dependence of zonal chondrocyte/MSC co-cultures in HA hydrogels for cartilage tissue engineering M. Kim, J.A. Burdick, R.L. Mauck Osteoarthritis and Cartilage Volume 21, Pages S307-S308 (April 2013) DOI: 10.1016/j.joca.2013.02.638 Copyright © 2013 Terms and Conditions

Fig 1 Co-culture of Zonal CHs and MSCs. Osteoarthritis and Cartilage 2013 21, S307-S308DOI: (10.1016/j.joca.2013.02.638) Copyright © 2013 Terms and Conditions

Fig 2. Visualization of CHs (Red) and MSCs (Green) (mixture ratio; CH:MSC = 1:4) and geometric changes of AbMSC- based constructs after 56 days of culture. (A-C) JbMSC-JbCH, (D-F) AbMSC-JbCH (10X; Scale bar=100 μm), (G) Co-cultures of AbMSCs and JbCHs at day 56 (Marking = 1 mm). Osteoarthritis and Cartilage 2013 21, S307-S308DOI: (10.1016/j.joca.2013.02.638) Copyright © 2013 Terms and Conditions

Fig 3 Mechanical and biochemical properties of co-cultures of zonal CHs and adult and juvenile bovine MSCs and efficacy of co-culture JbMSC – JbCH co-culture (A) Equilibrium Modulus (kPa) (B) GAG (%WW), AbMSC-JbCH co-culture (C) Equilibrium modulus (kPa), (D) GAG (%WW) (N = 4/Group; Lighter = Day 28, Darker = Day 56, *p<0.05). Efficacy of co-culture (E) Equilibrium modulus (kPa), (F) GAG (%WW) Osteoarthritis and Cartilage 2013 21, S307-S308DOI: (10.1016/j.joca.2013.02.638) Copyright © 2013 Terms and Conditions