Dysbiosis in Pouchitis: Evidence of Unique Microfloral Patterns in Pouch Inflammation  Srinadh Komanduri, Patrick M. Gillevet, Masoumeh Sikaroodi, Ece Mutlu, Ali Keshavarzian  Clinical Gastroenterology and Hepatology  Volume 5, Issue 3, Pages 352-360 (March 2007) DOI: 10.1016/j.cgh.2007.01.001 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 LH-PCR profiles of a Pouch Control sample in the lower panel and a Pouchitis sample in the upper panel. The profiles depicted in both panels are produced by the Genospectrum software (Spectrumedix LLC). Clinical Gastroenterology and Hepatology 2007 5, 352-360DOI: (10.1016/j.cgh.2007.01.001) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 (A) Stacked histogram of the averages of the normalized abundances from the LH-PCR analysis of washed and unwashed Pouch Control samples. (B) Stacked histogram of the averages of the normalized abundances from the LH-PCR analysis of Pouchitis mucosal samples from pouch and ileum. Clinical Gastroenterology and Hepatology 2007 5, 352-360DOI: (10.1016/j.cgh.2007.01.001) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 Stacked histogram of the averages of the normalized abundances from the LH-PCR analysis of lumen, ileum mucosa, and pouch mucosa from Pouchitis and Pouch Control patients. Clinical Gastroenterology and Hepatology 2007 5, 352-360DOI: (10.1016/j.cgh.2007.01.001) Copyright © 2007 AGA Institute Terms and Conditions

Figure 4 Principle Coordinate Analysis of Healthy Controls, Pouch Controls, and Active Pouchitis (PG) samples. The Eigen analysis was done using a Mean Character distance metric. The first principle component (vertical axis) and the second principle component (horizontal axis) account for 68% of the variance of the data. Samples are color coded as per their disease class and the Sample ID and PDAI index (in parenthesis) are shown for the Active Pouchitis samples. Clinical Gastroenterology and Hepatology 2007 5, 352-360DOI: (10.1016/j.cgh.2007.01.001) Copyright © 2007 AGA Institute Terms and Conditions

Figure 5 Box plot of ANOSIM analysis of Pouchitis and Healthy Control samples showing the differences between the mean rank order. *Mean between the a priori defined groups. Clinical Gastroenterology and Hepatology 2007 5, 352-360DOI: (10.1016/j.cgh.2007.01.001) Copyright © 2007 AGA Institute Terms and Conditions