Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy Ioannis Rotas, Giovanni Cito, Igor Letovanec,

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Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy Ioannis Rotas, Giovanni Cito, Igor Letovanec, Michel Christodoulou, Jean Y. Perentes The Annals of Thoracic Surgery Volume 101, Issue 2, Pages e51-e53 (February 2016) DOI: 10.1016/j.athoracsur.2015.09.023 Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) Digital clubbing as the initial presentation of a non-small cell lung cancer (NSCLC) in a patient. Typical features of hypertrophic osteoarthrpathy are clinically visible. (B) Complete disappearance of digital clubbing 3 months following left upper lobectomy with mediastinal adenectomy and adjuvant chemotherapy. (C) Distant recurrence of NSCLC with no recurrence of digital clubbing. The Annals of Thoracic Surgery 2016 101, e51-e53DOI: (10.1016/j.athoracsur.2015.09.023) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Positron emission tomography computed tomography scan demonstrating a Fluorodesoxyglucose (18F) avid left upper lobe mass with signs of parietal pleura infiltration. The Annals of Thoracic Surgery 2016 101, e51-e53DOI: (10.1016/j.athoracsur.2015.09.023) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 (A and B) Primary lung tumor immunostaining for cyclooxygenase-2 (COX2) shows a clear patchy expression pattern including areas with sparse expression and areas with intense expression. (C and D) Brain metastasis immunostaining for COX2 shows no expression in any part of the lesion although the primary tumor positive control is visible. The Annals of Thoracic Surgery 2016 101, e51-e53DOI: (10.1016/j.athoracsur.2015.09.023) Copyright © 2016 The Society of Thoracic Surgeons Terms and Conditions