European Urology Oncology Development and Validation of a Novel Prognostic Model for Predicting Overall Survival in Treatment-naïve Castration-sensitive Metastatic Prostate Cancer  Shusuke Akamatsu, Masashi Kubota, Ryuji Uozumi, Shintaro Narita, Masahiro Takahashi, Koji Mitsuzuka, Shingo Hatakeyama, Toshihiko Sakurai, Sadafumi Kawamura, Shigeto Ishidoya, Senji Hoshi, Masanori Ishida, Kei Mizuno, Keiji Ogura, Takayuki Goto, Naoki Terada, Takashi Kobayashi, Toshinari Yamasaki, Takahiro Inoue, Norihiko Tsuchiya, Chikara Ohyama, Yoichi Arai, Tomonori Habuchi, Satoshi Morita, Osamu Ogawa  European Urology Oncology  DOI: 10.1016/j.euo.2018.10.011 Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 1 Risk stratification based on the distribution of predicted hazard ratios. Each combination of risk factors (x-axis) was scored according to regression coefficients for the multivariable Cox model (Table 3). The y-axis shows the hazard ratio calculated for each combination. We defined three risk groups according to the risk scores: 0=low; <1.5=intermediate; and >1.5=high. GS=Gleason score; LDH=lactate dehydrogenase; EOD=extent of disease. European Urology Oncology DOI: (10.1016/j.euo.2018.10.011) Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 2 Overall survival stratified according to the novel prognostic model. Results are shown for (A) cases diagnosed in 2002 or later and (B) all patients in the discovery cohort. CI=confidence interval; NE=not estimable. European Urology Oncology DOI: (10.1016/j.euo.2018.10.011) Copyright © 2018 European Association of Urology Terms and Conditions

Fig. 3 Overall survival for the validation cohort stratified according to the novel prognostic model. CI=confidence interval; NE=not estimable. European Urology Oncology DOI: (10.1016/j.euo.2018.10.011) Copyright © 2018 European Association of Urology Terms and Conditions