Circadian Clock Control of Liver Metabolic Functions

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Presentation transcript:

Circadian Clock Control of Liver Metabolic Functions Hans Reinke, Gad Asher Gastroenterology Volume 150, Issue 3, Pages 574-580 (March 2016) DOI: 10.1053/j.gastro.2015.11.043 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 The core circadian oscillator. The activator proteins CLOCK and BMAL1 control the expression of Per, Cry, Nr1d, and Ror genes via E-box elements in their promoter regions. PER and CRY proteins repress their own transcription, generating a transcriptional and translational feedback loop. NR1D and ROR proteins form an auxiliary feedback loop by regulating Bmal1 expression. Gastroenterology 2016 150, 574-580DOI: (10.1053/j.gastro.2015.11.043) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 Circadian regulation of liver physiology. The hypothalamic master clock synchronizes peripheral oscillators, such as the liver clock, via rhythmic activity, feeding, and temperature cues. The liver clock drives the cyclic expression of master regulators and rate-limiting enzymes of key hepatic metabolic outputs. Gastroenterology 2016 150, 574-580DOI: (10.1053/j.gastro.2015.11.043) Copyright © 2016 AGA Institute Terms and Conditions