Internally and Externally Paced Finger Movements Differ in Reorganization After Acute Ischemic Stroke Torunn Askim, PhD, Bent Indredavik, PhD, MD, Asta.

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Internally and Externally Paced Finger Movements Differ in Reorganization After Acute Ischemic Stroke Torunn Askim, PhD, Bent Indredavik, PhD, MD, Asta Håberg, PhD, MD Archives of Physical Medicine and Rehabilitation Volume 91, Issue 10, Pages 1529-1536 (October 2010) DOI: 10.1016/j.apmr.2010.07.217 Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 1 Stroke site and maximum infarct volume for all included patients. Row 3 shows the hand knob region for all patients. Axial section through each subject's brain in acute phase and 12 weeks poststroke (ie, same time points as fMRI was performed). Yellow arrows point to stroke lesion sites and white arrow to the hand knob region. Images presented in neurologic convention, right is right. Abbreviations: DWI, diffusion-weighted imaging; FLAIR, fluid attenuation inversion recovery. *For subject 12, apparent diffusion coefficient (ADC) map of acute lesion is shown. Archives of Physical Medicine and Rehabilitation 2010 91, 1529-1536DOI: (10.1016/j.apmr.2010.07.217) Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 2 Upper section: brain areas with significant greater activation (q[FDR]<.05) in the controls compared with the stroke patients in the acute phase for the externally paced, 1Hz task to the left and the internal SP task to the right. Lower section: brain areas with significant greater activation (q[FDR]<.05) in the controls compared with the stroke patients in the chronic phase for the 1Hz task to the left. There were no significant differences in this comparison for the SP task. Activity overlaid on MNI template and coordinates in MNI space. Abbreviation: MNI, Montreal Neurological Institute. Archives of Physical Medicine and Rehabilitation 2010 91, 1529-1536DOI: (10.1016/j.apmr.2010.07.217) Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 3 Upper section: brain areas (blue) with significant (q[FDR]<.001) greater activation in the externally paced, 1Hz task compared with the internal SP task (1Hz>SP) in the controls. Lower section: brain areas (blue) with significantly (P<.01, uncorrected) greater activation in the 1Hz task compared with the SP task (1Hz>SP) and brain areas (yellow) with greater activation in the SP task compared with the 1Hz task (SP>1Hz) in stroke patients in the chronic phase. Activity overlaid on MNI template brain and coordinates in MNI space. Abbreviation: MNI, Montreal Neurological Institute. Archives of Physical Medicine and Rehabilitation 2010 91, 1529-1536DOI: (10.1016/j.apmr.2010.07.217) Copyright © 2010 American Congress of Rehabilitation Medicine Terms and Conditions