Volume 136, Issue 1, Pages (January 2009)

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Volume 136, Issue 1, Pages 131-137 (January 2009) Chromosome 8q23.3 and 11q23.1 Variants Modify Colorectal Cancer Risk in Lynch Syndrome Juul T. Wijnen, Richard M. Brohet, Ronald van Eijk, Shanty Jagmohan–Changur, Anneke Middeldorp, Carli M. Tops, Mario van Puijenbroek, Margreet G.E.M. Ausems, Encarna Gómez García, Frederik J. Hes, Nicoline Hoogerbrugge, Fred H. Menko, Theo A.M. van Os, Rolf H. Sijmons, Senno Verhoef, Anja Wagner, Fokko M. Nagengast, Jan H. Kleibeuker, Peter Devilee, Hans Morreau, David Goldgar, Ian P. Tomlinson, Richard S. Houlston, Tom van Wezel, Hans F.A. Vasen Gastroenterology Volume 136, Issue 1, Pages 131-137 (January 2009) DOI: 10.1053/j.gastro.2008.09.033 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 (A) Unadjusted overall cumulative CRC risk for MMR-gene carriers and allele rs16892766. (B) Unadjusted cumulative CRC risk for male MMR-gene carriers and allele rs16892766. Gastroenterology 2009 136, 131-137DOI: (10.1053/j.gastro.2008.09.033) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 (A) Unadjusted overall cumulative CRC risk for MMR-gene carriers and allele rs3802842. (B) Unadjusted cumulative CRC risk for male MMR-gene carriers and allele rs3802842. (C) Unadjusted cumulative CRC risk for female MMR-gene carriers and allele rs3802842. Gastroenterology 2009 136, 131-137DOI: (10.1053/j.gastro.2008.09.033) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 (A) CRC risk in male carriers according to number of risk alleles of rs3802842 and rs16892766 adjusted for birth cohort and type of MMR gene. (B) CRC risk in female carriers according to number of risk alleles of rs3802842 and rs16892766 adjusted for birth cohort and type of MMR gene. Gastroenterology 2009 136, 131-137DOI: (10.1053/j.gastro.2008.09.033) Copyright © 2009 AGA Institute Terms and Conditions