Volume 382, Issue 9900, Pages (October 2013)

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Volume 382, Issue 9900, Pages 1249-1257 (October 2013) Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial Prof Stephen J Allen, MD, Kathie Wareham, MPH, Duolao Wang, PhD, Caroline Bradley, MSc, Hayley Hutchings, PhD, Wyn Harris, FRCP, Anjan Dhar, MD, Helga Brown, FRCP, Alwyn Foden, FRCP, Prof Michael B Gravenor, DPhil, Prof Dietrich Mack, MD The Lancet Volume 382, Issue 9900, Pages 1249-1257 (October 2013) DOI: 10.1016/S0140-6736(13)61218-0 Copyright © 2013 Allen et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile *Identity of trial intervention unknown because of an error in labelling at one hospital site. † Second enrolment in study excluded because of possible carry-over effects from first enrolment in study. The Lancet 2013 382, 1249-1257DOI: (10.1016/S0140-6736(13)61218-0) Copyright © 2013 Allen et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Duration of hospital admission in all participants The Lancet 2013 382, 1249-1257DOI: (10.1016/S0140-6736(13)61218-0) Copyright © 2013 Allen et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 3 Number of days participants took the trial interventions The Lancet 2013 382, 1249-1257DOI: (10.1016/S0140-6736(13)61218-0) Copyright © 2013 Allen et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 4 Meta-analysis of trials of lactobacilli or bifidobacteria, or both, in the prevention of antibiotic-associated diarrhoea in older inpatients *From Mantel-Haenszel fixed effects analysis. The Lancet 2013 382, 1249-1257DOI: (10.1016/S0140-6736(13)61218-0) Copyright © 2013 Allen et al. Open Access article distributed under the terms of CC BY Terms and Conditions