Volume 142, Issue 1, Pages 46-54.e42 (January 2012) Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review  Natalie A. Molodecky, Ing Shian Soon, Doreen M. Rabi, William A. Ghali, Mollie Ferris, Greg Chernoff, Eric I. Benchimol, Remo Panaccione, Subrata Ghosh, Herman W. Barkema, Gilaad G. Kaplan  Gastroenterology  Volume 142, Issue 1, Pages 46-54.e42 (January 2012) DOI: 10.1053/j.gastro.2011.10.001 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Literature search results. Gastroenterology 2012 142, 46-54.e42DOI: (10.1053/j.gastro.2011.10.001) Copyright © 2012 AGA Institute Terms and Conditions

Figure 2 Worldwide CD incidence rates and/or prevalence for countries reporting data (A) before 1960, (B) from 1960 to 1979, and (C) after 1980. Incidence and prevalence values were ranked into quintiles representing low (dark and light blue) to intermediate (green) to high (yellow and red) occurrence of disease. Gastroenterology 2012 142, 46-54.e42DOI: (10.1053/j.gastro.2011.10.001) Copyright © 2012 AGA Institute Terms and Conditions

Figure 3 Worldwide UC incidence rates and/or prevalence for countries reporting data (A) before 1960, (B) from 1960 to 1979, and (C) after 1980. Incidence and prevalence values were ranked into quintiles representing low (dark and light blue) to intermediate (green) to high (yellow and red) occurrence of disease. Gastroenterology 2012 142, 46-54.e42DOI: (10.1053/j.gastro.2011.10.001) Copyright © 2012 AGA Institute Terms and Conditions

Figure 4 Temporal trends of incidence rates for studies that reported at least 10 years of data and with at least 3 time points for (A) CD and (B) UC. Gastroenterology 2012 142, 46-54.e42DOI: (10.1053/j.gastro.2011.10.001) Copyright © 2012 AGA Institute Terms and Conditions

Appendix 6 Worldwide Crohn’s disease incidence rates for countries reporting data before (a) 1960, (b) from 1960 to 1979, and (c) after 1980. Worldwide ulcerative colitis incidence rates for countries reporting data before (d) 1960, (e) from 1960 to 1979, and (f) after 1980. Incidence rates were ranked into quintiles representing low (dark and light blue) to intermediate (green) to high (yellow and red) incidence of disease. Gastroenterology 2012 142, 46-54.e42DOI: (10.1053/j.gastro.2011.10.001) Copyright © 2012 AGA Institute Terms and Conditions

Appendix 7 Worldwide Crohn’s disease prevalence for countries reporting data before (a) 1960, (b) from 1960 to 1979, and (c) after 1980. Worldwide ulcerative colitis prevalence for countries reporting data before (d) 1960, (e) from 1960 to 1979, and (f) after 1980. Incidence rates were ranked into quintiles representing low (dark and light blue) to intermediate (green) to high (yellow and red) incidence of disease. Gastroenterology 2012 142, 46-54.e42DOI: (10.1053/j.gastro.2011.10.001) Copyright © 2012 AGA Institute Terms and Conditions