Proteins: Quaternary structure

Slides:

Advertisements

Similar presentations

Metabolic effects of CO 2 Alice Skoumalová. Overview of oxidative fuel metabolism:

Advertisements

Review exam questions. XxwY.

Transport of Gases Presents to you by ABOUT DISEASE.CO TEAM.

Transport of CO 2 Dissolved in plasma As bicarbonate ions As carbamino Hb or Carbamino Proteins Under normal resting conditions,an average of 4 ml of CO.

GAS TRANSPORT OXYGEN(O2) & CARBONDIOXIDE(CO2)

Myoglobin and Hemoglobin

Lect. 8-1 Globular Proteins Some design principles Globular proteins fold so as to "bury" the hydrophobic side chains, minimizing their contact with water.

The Respiratory System: Gas Exchange and Regulation of Breathing

Biochemistry Sixth Edition

Internal Gas Transport (“Blood”) Chapter 22 Functions of “Blood” Gas Transport Nutrient Transport Excretory Product Transport Cell Signal Transport Hydraulic.

H.6 Gas Exchange. Hemoglobin  Hemoglobin is a protein found in RBC’s composed of 4 polypeptides, each polypeptide containing a heme group. Each heme.

1 Respiratory system L4 Faisal I. Mohammed, MD, PhD University of Jordan.

AP Biology Why do we need a respiratory system? O2O2 food ATP CO 2  Need O 2 in  for aerobic cellular respiration  make ATP  Need CO 2 out  waste.

CHMI E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Levels of Protein Structure - Conformation of Peptide Group.

Ventilation/Perfusion Ratios in the Lung. O 2 Transport in the Blood O 2 is bound to hemoglobin (Hb) for transport in the blood –Oxyhemoglobin: O 2 bound.

Chapter 22 Respiratory System Lecture 8 Part 2: O2 and CO2 Transport

External and Internal Respiration. Learning Outcomes: C10 – Analyse internal and external respiration –State location –Describe conditions (ph, temperature)

Carbon Dioxide Transport

Transport of Oxygen and carbon dioxide

CHMI E.R. Gauthier, Ph.D. 1 CHMI 2227E Biochemistry I Proteins: - Quaternary structure.

Hemoglobin, an AllostericProtein. Hemoglobin vs Myoglobin Hemoglobin (Hb): - found in red blood cells - responsible for transport of O 2 from lungs to.

Carriage of respiratory Gases By Y Stock. Objectives  You should be able to:  Describe the structure of erythrocytes.  Describe the role of respiratory.

Transport of O 2 & CO 2. Transport of O 2 Oxygen in blood bound to hemoglobin (98.5%) dissolved in the plasma (1.5%) Almost all oxygen in the blood is.

Hemoglobin, an Allosteric Protein Stryer Short Course.

1 Human erythrocytes (red blood cells) Erythrocytes are small disk-shaped cells in the blood. They have lost their intracellular organelles, can not reproduce.

Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings Concept 42.7: Respiratory pigments bind and transport gases The metabolic demands.

3-D Structure / Function. Myoglobin/ Hemoglobin First protein structures determined Oxygen carriers Hemoglobin transport O 2 from lungs to tissues Myoglobin.

Hubert Kairuki Memorial University Faculty of medicine-FOM

Structure Hemoglobin –Tetramer of  2  2 –Each subunit binds one heme –Oxygen transporter in RBCs Myoglobin –Monomer with one heme –Oxygen reservoir.

Oxygen Transport and Asphyxia AnS 536 Spring 2016.

Biochemistry Kay Iwelumo. Objectives Proteins- Composition/Structure Protein Purification Enzymes- Kinetics and Inhibition Hemoglobin/Myoglobin Membrane-

Oxygen transport by the blood O2 in physical solution O2 in physical solution The O2 in physical solution determines the PO2 in the blood and therefore.

Hemoglobin and Myoglobin These are conjugated proteins.A simple protein has only a polypeptide chain. A conjugated protein has a non-protein part in addition.

 the diaphragm  the abdominal muscles  atmospheric pressure  the external intercostal muscles.

Gas Exchange Part 2: Gas Exchange and Oxygen Dissociation

Biochemical role of Hemoglobin

Transport of Respiratory Gases

F211: Exchange & transport

Structure and function of hemoglobin

RESPIRATORY SYSTEM LECTURE-6 (GAS TRANSPORT)

HEMOGLOBIN Biochemistry (BMS 233) L.Noha Soliman.

HAEMOGLOBIN Lesson Objectives:

GLOBULAR HEMOPROTEINS

Module 2 – Exchange and Transport

Oxygen saturation curves for myoglobin and hemoglobin

D.6: Transport of respiratory gases

Gas Exchange HCS 1070 SLO:

Respiratory System Gas Exchange.

Faisal I. Mohammed, MD, PhD

OXYGEN(O2) & CARBONDIOXIDE(CO2)

Comparative Vertebrate Physiology

Chapter 22 – The Respiratory System

Chapter 19.6 Gas Transport Kiana, Heather, Kalli.

Proteins: Tertiary structure

Transport of Respiratory Gases

Transport of CO2.

Structure and function of hemoglobin

External and Internal Respiration

Respiratory System 6.4 & D6.

Respiratory System 6.4 & H6.

Chapter 42 Continued Respiratory System.

Respiration External Respiration:

RESPIRATION Internal vs. external.

Gas Exchange and Transport

9.1 Respiratory System.

Respiration: Part 3 How does gas exchange happen?

Respiration: Part 3 How does gas exchange happen?

Presentation transcript:

Proteins: Quaternary structure CHMI 2227E Biochemistry I Proteins: Quaternary structure CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure hydrophobic hydrophilic Porin: a trimeric membrane-bound protein hydrophobic hydrophilic CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure Hemoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure Hemoglobin HbA vs myoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure Oxygen binding by Hb and myoglobin CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure Oxygen binding by Hb and myoHb CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure Oxygen binding by Hb and myoHb CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure Oxygen binding by Hb and myoHb CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure O2 binding changes the 3-D shape of Hb CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure O2 binding changes the 3-D shape of Hb CHMI 2227 - E.R. Gauthier, Ph.D. http://upload.wikimedia.org/wikipedia/commons/0/07/Hb-animation2.gif

Quaternary structure Hb is an allosteric protein Low affinity High affinity Saturated O2 CHMI 2227 - E.R. Gauthier, Ph.D.

Quaternary structure Why Hb is allosteric, while Myoglobin is not? CHMI 2227 - E.R. Gauthier, Ph.D.

The Bohr effect CHMI 2227 - E.R. Gauthier, Ph.D. http://www.aw-bc.com/mathews/ch07/fi7p16.htm CHMI 2227 - E.R. Gauthier, Ph.D.

Gas exchange In the tissues Erythrocytes Glucose + O2 ATP CO2 H2O Carbonic anhydrase H2CO3 HCO3- H+ Plasma (to lungs) Hb-4O2 Hb-H+ 4O2 H2O + Cl- CHMI 2227 - E.R. Gauthier, Ph.D.

Gas exchange In the lungs CO2 CO2 CO2 H2O Carbonic anhydrase H2CO3 Air Hb-4O2 H2O + Cl- HCO3- HCO3- H+ Hb-H+ 4O2 O2 O2 Plasma Erythrocytes Lungs CHMI 2227 - E.R. Gauthier, Ph.D.