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Volume 122, Issue 2, Pages 387-393 (February 2002) 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: A possible role of cysteinyl-leukotrienes Mariona Graupera, Juan–Carlos García–Pagán, Esther Titos, Joan Claria, Anna Massaguer, Jaime Bosch, Juan Rodés Gastroenterology Volume 122, Issue 2, Pages 387-393 (February 2002) DOI: 10.1053/gast.2002.31040 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 Cys-LT production in control and CCl4-induced cirrhotic perfused livers. An increased production of Cys-LTs was observed in CCl4-induced cirrhotic livers. Values represent means ± SE. *P < 0.01. Gastroenterology 2002 122, 387-393DOI: (10.1053/gast.2002.31040) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 Cys-LTs production was significant and positively correlated with baseline portal PP. Gastroenterology 2002 122, 387-393DOI: (10.1053/gast.2002.31040) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 3 Portal PP dose–response to LTD4 At all tested doses, the increase in PP after LTD4 was significantly greater in CCl4-induced cirrhotic than in control livers. *P < 0.01 Gastroenterology 2002 122, 387-393DOI: (10.1053/gast.2002.31040) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 4 Effect on PP of 5-LO inhibition with AA-861 (10 μmol/L) in (A) control and (B) CCl4-induced cirrhotic livers preconstricted with Mtx. 5-LO inhibition produced a significant reduction in PP in both control or cirrhotic livers. Data represent means ± SE. *P < 0.01. Gastroenterology 2002 122, 387-393DOI: (10.1053/gast.2002.31040) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 5 Comparison of the effects of 5-LO inhibition with AA-861 (10 μmol/L) in control (n = 6) and CCl4-induced cirrhotic (n = 10) livers. Reduction of PP after AA-861 was significantly greater in cirrhotic than in control livers. Gastroenterology 2002 122, 387-393DOI: (10.1053/gast.2002.31040) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 6 Effect on PP of MK-571 (1 μmol/L) or AA-861(10 μmol/L) in (A) control and (B) CCl4-induced cirrhotic livers preconstricted with Mtx. In controls, a mild and similar reduction in PP was observed after MK-571 or AA-861. Changes in PP in cirrhotic livers were significantly greater after AA-861 than after MK-571. *P < 0.01 Gastroenterology 2002 122, 387-393DOI: (10.1053/gast.2002.31040) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 7 5-LO staining of liver sections from (A, B) control and (C, D) CCl4-induced cirrhotic rats. Sections were incubated with (A, C) PBS–1% BSA as negative control or (B, D) anti–5-LO antiserum. 5-LO–positive cells (open arrows) were markedly increased in CCl4 cirrhotic livers (D) and mainly located along inter nodular septa. Solid arrows indicate autoflurescence of collagen fibers in fibrous septa. Gastroenterology 2002 122, 387-393DOI: (10.1053/gast.2002.31040) Copyright © 2002 American Gastroenterological Association Terms and Conditions