A classification of plant food allergens Heimo Breiteneder, PhD, Christian Radauer, PhD  Journal of Allergy and Clinical Immunology  Volume 113, Issue 5, Pages 821-830 (May 2004) DOI: 10.1016/j.jaci.2004.01.779

FIG 1 Structures of proteins from the cupin superfamily. A, Barley germin monomer (Protein Data Bank accession no. 1FIZ), a protein containing one cupin domain. B, Single subunit of soybean β-conglycinin, a vicilin (1IPK). C, Single subunit of soybean proglycinin, a legumin (1FXZ). D and E, Molecular surfaces of the trimers of β-conglycinin and proglycinin. Blue, α-helices; red, β-strands; yellow, disulfide bonds; green, manganese ion. Journal of Allergy and Clinical Immunology 2004 113, 821-830DOI: (10.1016/j.jaci.2004.01.779)

FIG 2 Secondary structures of allergens from the prolamin superfamily. A, Rapeseed 2S albumin (napin BNIb, Protein Data Bank accession no. 1PNB). B, Barley nsLTP (1LIP). C, Wheat α-amylase inhibitor (1HSS). D, Soybean hydrophobic seed protein (1HYP). Blue, α-helices; red, β-strands; yellow, disulfide bonds. Journal of Allergy and Clinical Immunology 2004 113, 821-830DOI: (10.1016/j.jaci.2004.01.779)

FIG 3 Stabilization of allergen structures by disulfide bonds. A, Hevein (Hev b 6.02), the major Hevea brasiliensis latex allergen (Protein Data Bank accession no. 1HEV). B, Zeamatin from Zea mays, a member of the PR-5 (TLP) family (1DU5). C, The major kiwifruit allergen actinidin (Act c 1), a papain-like cysteine protease (2ACT). Blue, α-Helices; red, β-strands; yellow, disulfide bonds. Journal of Allergy and Clinical Immunology 2004 113, 821-830DOI: (10.1016/j.jaci.2004.01.779)