Antimicrobial peptides and the skin immune defense system

Slides:



Advertisements
Similar presentations
Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.
Advertisements

Identification and functions of pattern-recognition receptors
Doina M. Racila, MD, Joel N. Kline, MD, MSc 
Roles of Mas-related G protein–coupled receptor X2 on mast cell–mediated host defense, pseudoallergic drug reactions, and chronic inflammatory diseases 
Natalija Novak, MD  Journal of Allergy and Clinical Immunology 
Endotype-driven care pathways in patients with chronic rhinosinusitis
Mechanisms of nutrient modulation of the immune response
Laurent L'homme, PhD, David Dombrowicz, PhD 
Advances in food allergy in 2015
Primary immunodeficiency diseases associated with increased susceptibility to viral infections and malignancies  Nima Rezaei, MD, PhD, Mona Hedayat, MD,
Identification and functions of pattern-recognition receptors
Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis  Eva Gros, MSc, Susanne Petzold,
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
The role of viruses in acute exacerbations of asthma
Atopic dermatitis: Age and race do matter!
Prostaglandin E2 suppresses CCL27 production through EP2 and EP3 receptors in human keratinocytes  Naoko Kanda, MD, PhD, Hiroshi Mitsui, MD, PhD, Shinichi.
The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology  Mate Kiss, Zsolt Czimmerer,
Signaling molecules as therapeutic targets in allergic diseases
Therapeutic pipeline for atopic dermatitis: End of the drought?
Is 9 more than 2 also in allergic airway inflammation?
Thomas F. Tedder, PhD, Takashi Matsushita, MD, PhD 
Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling  David Bending, PhD,
TNF-α–induced protein 3 (A20): The immunological rheostat
David J. Cousins, PhD, Joanne McDonald, BSc, Tak H. Lee, MD, ScD 
Toluene downregulates filaggrin expression via the extracellular signal-regulated kinase and signal transducer and activator of transcription–dependent.
Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J
Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF- β1–stimulated primary human fibroblasts  Xiuxia Zhou, PhD, Haizhen.
Potential mechanisms for the hypothesized link between sunshine, vitamin D, and food allergy in children  Milo F. Vassallo, MD, PhD, Carlos A. Camargo,
MicroRNAs: Essential players in the regulation of inflammation
Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor–dependent innate antiviral immune responses  Douglas R. McDonald, MD, PhD,
Immune modulation by neuronal electric shock waves
TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection  Mübeccel Akdis, MD, PhD, Oscar Palomares, PhD,
Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages  Elena Goleva, PhD, Pia J. Hauk, MD, Clifton.
Inflammatory health effects of indoor and outdoor particulate matter
Peter M. Wolfgram, MD, David B. Allen, MD 
Epithelium: At the interface of innate and adaptive immune responses
Biologics and biomarkers for asthma, urticaria, and nasal polyposis
Role of IgE in autoimmunity
Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation  Leif Bjermer, MD  Journal of Allergy.
Charles E. Reed, MD, Hirohito Kita, MD 
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management  Scott H. Sicherer, MD, Hugh A. Sampson, MD  Journal.
Biosimilars and drug development in allergic and immunologic diseases
Update on the role of prostaglandins in allergic lung inflammation: Separating friends from foes, harder than you might think  Martin L. Moore, PhD, R.
Weiguo Chen, PhD, Gurjit K. Khurana Hershey, MD, PhD 
Liam O’Mahony, PhD, Mübeccel Akdis, MD, PhD, Cezmi A. Akdis, MD 
H. William Kelly, PharmD  Journal of Allergy and Clinical Immunology 
Autophagy: Nobel Prize 2016 and allergy and asthma research
IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets  Sven Létourneau, DPhil, Carsten Krieg, PhD, Giuseppe Pantaleo,
Advances in the approach to the patient with food allergy
Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E
New pathways for itching in patients with atopic dermatitis?
Chemokines and their receptors in allergic disease
Primary immunodeficiencies may reveal potential infectious diseases associated with immune-targeting mAb treatments  László Maródi, MD, PhD, Jean-Laurent.
Innate immunity Journal of Allergy and Clinical Immunology
Targeting TNF-α: A novel therapeutic approach for asthma
Does “autoreactivity” play a role in atopic dermatitis?
Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell–mediated allergic inflammation  Yong-Jun Liu, MD, PhD  Journal.
Innate immune responses to infection
Stefan Schülke, PhD, Stefan Vieths, PhD 
Macrolide antibiotics and asthma treatment
Vitamin D in allergic disease: Shedding light on a complex problem
Immune pathomechanism of drug hypersensitivity reactions
Asthma: The past, future, environment, and costs
Environmental factors and eosinophilic esophagitis
Contrasting pathogenesis of atopic dermatitis and psoriasis—Part II: Immune cell subsets and therapeutic concepts  Emma Guttman-Yassky, MD, PhD, Kristine.
Natural history of cow’s milk allergy
Primary prevention of asthma and allergy
Itching as a systemic disease
Chitinases and chitinase-like proteins in TH2 inflammation and asthma
Epigenetic mechanisms and the development of asthma
Presentation transcript:

Antimicrobial peptides and the skin immune defense system Jürgen Schauber, MD, Richard L. Gallo, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 122, Issue 2, Pages 261-266 (August 2008) DOI: 10.1016/j.jaci.2008.03.027 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Models for cell activation by cathelicidins. Multiple mechanisms have been proposed for cathelicidins to stimulate a cellular response. Responses are dependent on activation of G protein–coupled receptors and transactivation of the epidermal growth factor receptor or secondary to intracellular Ca2+ mobilization or a change in cell membrane function, leading to alterations in receptor responses. Finally, cathelicidins can influence the function of TLRs through both direct and indirect pathways. EGF-R, Epidermal growth factor receptor; IP-10, IFN-γ–inducible protein 10; MCP-1, monocyte chemoattractant protein 1; MIP3α, macrophage inflammatory protein 3α; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; STAT, signal transducer and activator of transcription. Journal of Allergy and Clinical Immunology 2008 122, 261-266DOI: (10.1016/j.jaci.2008.03.027) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Mechanisms of vitamin D3 activation and cathelicidin response. Extrarenal metabolism of vitamin D3 by keratinocytes provides a system for rapid control of cathelicidin expression. Activation of 25D3 to 1,25D3 requires 2 hydroxylation steps that occur sequentially in the liver and kidney. However, keratinocytes also express CYP27B1, a 1α-hydroxylase that activates 1,25D3. CYP27B1 expression in keratinocytes is controlled by danger signals during skin infection and tissue damage. Journal of Allergy and Clinical Immunology 2008 122, 261-266DOI: (10.1016/j.jaci.2008.03.027) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions